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Genetics of dopamine receptors and drug addiction: a comprehensive review
Le Foll, Bernard1; Gallo, Alexandra1; Le Strat, Yann3,4; Lu, Lin2; Gorwood, Philip3,4
关键词Addiction Alcohol Dopamine Genetic Nicotine Opiates Psychostimulant Receptors
刊名BEHAVIOURAL PHARMACOLOGY
2009-02-01
DOI10.1097/FBP.0b013e3283242f05
20期:1页:1-17
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS SHELL ; VENTRAL TEGMENTAL AREA ; DRD4 VNTR POLYMORPHISM ; EXON-III POLYMORPHISM ; PREFERRING P-RATS ; TAQI A1 ALLELE ; ALCOHOL-DEPENDENT MEN ; KNOCK-OUT MICE
英文摘要

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behaviours persist despite serious negative consequences. Addictive substances, such as opioids, ethanol, psychostimulants and nicotine, induce pleasant states or relieve distress, effects that contribute to their recreational use. Dopamine is critically involved in drug addiction processes. However, the role of the various dopaminergic receptor subtypes has been difficult to delineate. Here, we will review the information collected implicating the receptors of the D-1 family (DRD1 and DRDS) and of the D-2 family (DRD2, DRD3 and DRDQ) in drug addiction. We will summarize the distribution of these receptors in the brain, the preclinical experiments carried out with pharmacological and transgenic approaches and the genetic studies carried out linking genetic variants of these receptors to drug addiction phenotypes. A meta-analysis of the studies carried out evaluating DRD2 and alcohol dependence is also provided, which indicates a significant association. Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans. Behavioural Pharmacology 20:1-17 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种英语
WOS记录号WOS:000263895000001
引用统计
被引频次:165[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57674
专题中国药物依赖性研究所
作者单位1.Univ Paris 07, Paris, France
2.INSERM, U675, Paris, France
3.Univ Toronto, Ctr Addict & Mental Hlth, Translat Addict Res Lab, Toronto, ON M5S 2S1, Canada
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Le Foll, Bernard,Gallo, Alexandra,Le Strat, Yann,et al. Genetics of dopamine receptors and drug addiction: a comprehensive review[J]. BEHAVIOURAL PHARMACOLOGY,2009,20(1):1-17.
APA Le Foll, Bernard,Gallo, Alexandra,Le Strat, Yann,Lu, Lin,&Gorwood, Philip.(2009).Genetics of dopamine receptors and drug addiction: a comprehensive review.BEHAVIOURAL PHARMACOLOGY,20(1),1-17.
MLA Le Foll, Bernard,et al."Genetics of dopamine receptors and drug addiction: a comprehensive review".BEHAVIOURAL PHARMACOLOGY 20.1(2009):1-17.
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