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学科主题: 药物依赖
题名:
Genetics of dopamine receptors and drug addiction: a comprehensive review
作者: Le Foll, Bernard1; Gallo, Alexandra1; Le Strat, Yann3,4; Lu, Lin2; Gorwood, Philip3,4
关键词: addiction ; alcohol ; dopamine ; genetic ; nicotine ; opiates ; psychostimulant ; receptors
刊名: BEHAVIOURAL PHARMACOLOGY
发表日期: 2009-02-01
DOI: 10.1097/FBP.0b013e3283242f05
卷: 20, 期:1, 页:1-17
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS SHELL ; VENTRAL TEGMENTAL AREA ; DRD4 VNTR POLYMORPHISM ; EXON-III POLYMORPHISM ; PREFERRING P-RATS ; TAQI A1 ALLELE ; ALCOHOL-DEPENDENT MEN ; KNOCK-OUT MICE
英文摘要:

Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behaviours persist despite serious negative consequences. Addictive substances, such as opioids, ethanol, psychostimulants and nicotine, induce pleasant states or relieve distress, effects that contribute to their recreational use. Dopamine is critically involved in drug addiction processes. However, the role of the various dopaminergic receptor subtypes has been difficult to delineate. Here, we will review the information collected implicating the receptors of the D-1 family (DRD1 and DRDS) and of the D-2 family (DRD2, DRD3 and DRDQ) in drug addiction. We will summarize the distribution of these receptors in the brain, the preclinical experiments carried out with pharmacological and transgenic approaches and the genetic studies carried out linking genetic variants of these receptors to drug addiction phenotypes. A meta-analysis of the studies carried out evaluating DRD2 and alcohol dependence is also provided, which indicates a significant association. Overall, this review indicates that different aspects of the addiction phenotype are critically influenced by dopaminergic receptors and that variants of those genes seem to influence some addiction phenotypes in humans. Behavioural Pharmacology 20:1-17 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000263895000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57674
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Univ Paris 07, Paris, France
2.INSERM, U675, Paris, France
3.Univ Toronto, Ctr Addict & Mental Hlth, Translat Addict Res Lab, Toronto, ON M5S 2S1, Canada
4.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Le Foll, Bernard,Gallo, Alexandra,Le Strat, Yann,et al. Genetics of dopamine receptors and drug addiction: a comprehensive review[J]. BEHAVIOURAL PHARMACOLOGY,2009,20(1):1-17.
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