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学科主题基础医学
Lysosomal-Associated Protein Transmembrane 4 Beta-35 Overexpression Is a Novel Independent Prognostic Marker for Gastric Carcinoma
Liu, Luying1,2; Xu, Xuefang1; Jing, Lili3; Zhou, Gengyin2; Cao, Zhang1; Han, Yanchun1; Zhou, Rouli4
刊名PLOS ONE
2015-02-17
DOI10.1371/journal.pone.0118026
10期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]LAPTM4B GENE POLYMORPHISM ; RURAL CHINESE POPULATION ; HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; GALLBLADDER CARCINOMA ; OVARIAN-CARCINOMA ; POOR-PROGNOSIS ; CANCER ; EXPRESSION ; CELLS
英文摘要

Objective

The purpose of this work was to analyze the relationships between the expression status of Lysosomal-associated protein transmembrane-4 beta 35 (LAPTM4B-35) in cancerous tissues and clinicopathological characteristics and prognosis of the patients with gastric carcinoma (GC).

Methods

The GC samples from 157 patients in a discovery cohort and 148 patients in a testing cohort with follow-up data were used to validate the feasibility of expression of LAPTM4B-35 protein in predicting GC prognosis. Immunohistochemical staining was used to determine the expression of LAPTM4B-35 protein in precancerous gastric lesions and gastric carcinomas. The correlation between the expression of LAPTM4B-35 and clinicopathologic characteristics of patients with gastric carcinoma was analyzed using chi-square test. Univariate and multivariate analyses were performed to determine the association between LAPTM4B-35 expression and prognosis.

Results

LAPTM4B-35 expression was increased steadily in sequential stages of precancerous gastric lesions. Positive LAPTM4B-35 expression was more frequently detected in patients with distant metastasis (P = 0.023) and III+ IV TNM stages (P = 0.042) in the discovery cohort. Kaplan-Meier survival curves and univariate analysis showed that expression of LAPTM4B-35 had a significant impact on overall survival of patients with gastric carcinoma in discovery cohort (P < 0.001) and testing cohort (P = 0.001). LAPTM4B-35 expression was an independent prognostic indicator for the overall survival of patients with gastric carcinoma in both cohorts.

Conclusions

The present research demonstrated that LAPTM4B-35 over-expression was an independent factor in gastric carcinoma prognosis. LAPTM4B gene may be a useful target of interventions slowing the progression of precancerous gastric lesions and a new therapy method to improve the prognosis of gastric carcinoma.

语种英语
WOS记录号WOS:000350322700095
项目编号ZR2011HM073 ; ZR2011HQ025
资助机构Natural Science Foundation of Shandong Province
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57678
专题北京大学基础医学院
作者单位1.Binzhou Med Univ, Dept Pathol, Yantai, Shandong, Peoples R China
2.Shandong Univ, Sch Med, Dept Pathol & Pathophysiol, Jinan 250100, Shandong, Peoples R China
3.Binzhou Med Univ, Yantai Affiliated Hosp, Dept Pathol, Yantai, Shandong, Peoples R China
4.Peking Univ, Dept Cell Biol & Genet, Sch Basic Med Sci, Beijing 100871, Peoples R China
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GB/T 7714
Liu, Luying,Xu, Xuefang,Jing, Lili,et al. Lysosomal-Associated Protein Transmembrane 4 Beta-35 Overexpression Is a Novel Independent Prognostic Marker for Gastric Carcinoma[J]. PLOS ONE,2015,10(2).
APA Liu, Luying.,Xu, Xuefang.,Jing, Lili.,Zhou, Gengyin.,Cao, Zhang.,...&Zhou, Rouli.(2015).Lysosomal-Associated Protein Transmembrane 4 Beta-35 Overexpression Is a Novel Independent Prognostic Marker for Gastric Carcinoma.PLOS ONE,10(2).
MLA Liu, Luying,et al."Lysosomal-Associated Protein Transmembrane 4 Beta-35 Overexpression Is a Novel Independent Prognostic Marker for Gastric Carcinoma".PLOS ONE 10.2(2015).
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