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学科主题临床医学
Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor
Dong, Yujun1; Wang, Mingyue2; Nong, Lin3; Wang, Lihong1; Cen, Xinan1; Liu, Wei1; Zhu, Sainan4; Sun, Yuhua1; Liang, Zeyin1; Li, Yuan1; Ou, Jinping1; Qiu, Zhixiang1; Ren, Hanyun1
关键词Castleman Disease Clinical Complications Paraneoplastic Pemphigus Survival Analysis Prognostic Factors
刊名BRITISH JOURNAL OF HAEMATOLOGY
2015-06-01
DOI10.1111/bjh.13378
169期:6页:834-842
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]RECEPTOR ANTIBODY ; AUTOANTIBODY ; TOCILIZUMAB ; THALIDOMIDE ; RITUXIMAB ; THYMOMA ; TUMOR
英文摘要

This study retrospectively collected the clinical and laboratory data of 114 patients with Castleman disease (CD) from a single medical centre. Clinical classification identified 62 patients (544%) with unicentric Castleman disease and 52 (456%) with multi-centric Castleman disease. Pathological classification revealed 68 cases (596%) of hyaline vascular variant, 16 (141%) mixed cellular variant (Mix) and 30 (263%) plasmacytic variant. Clinical complications occurred in 69 CD patients, including 37 cases of paraneoplastic pemphigus (PNP) and 25 cases with renal complications. Haematological involvement, pleural effusion and/or ascites and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) were also found. Univariate analysis showed that presence of clinical complications and PNP were both risk factors relating to CD patient survival. Prognostic factors showing P<015 in univariate analysis and those with clinical significance were subjected to multivariate analysis using a Cox regression model. PNP presence and age over 40years both significantly adversely affected survival. Thus, only presence of PNP was identified as an independent unfavourable survival risk factor in both univariate and multivariate analyses. Overall, the present data provide a panoramic description of CD cases and emphasize that the presence of PNP is an adverse prognostic factor.

语种英语
WOS记录号WOS:000355657300011
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57680
Collection北京大学第一临床医学院
北京大学第一临床医学院_皮肤性病科
北京大学第一临床医学院_血液内科
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Dept Haematol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Dept Pathol, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, Dept Biostat, Hosp 1, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Dong, Yujun,Wang, Mingyue,Nong, Lin,et al. Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor[J]. BRITISH JOURNAL OF HAEMATOLOGY,2015,169(6):834-842.
APA Dong, Yujun.,Wang, Mingyue.,Nong, Lin.,Wang, Lihong.,Cen, Xinan.,...&Ren, Hanyun.(2015).Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor.BRITISH JOURNAL OF HAEMATOLOGY,169(6),834-842.
MLA Dong, Yujun,et al."Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor".BRITISH JOURNAL OF HAEMATOLOGY 169.6(2015):834-842.
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