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学科主题: 临床医学
题名:
Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor
作者: Dong, Yujun1; Wang, Mingyue2; Nong, Lin3; Wang, Lihong1; Cen, Xinan1; Liu, Wei1; Zhu, Sainan4; Sun, Yuhua1; Liang, Zeyin1; Li, Yuan1; Ou, Jinping1; Qiu, Zhixiang1; Ren, Hanyun1
关键词: Castleman disease ; clinical complications ; paraneoplastic pemphigus ; survival analysis ; prognostic factors
刊名: BRITISH JOURNAL OF HAEMATOLOGY
发表日期: 2015-06-01
DOI: 10.1111/bjh.13378
卷: 169, 期:6, 页:834-842
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: RECEPTOR ANTIBODY ; AUTOANTIBODY ; TOCILIZUMAB ; THALIDOMIDE ; RITUXIMAB ; THYMOMA ; TUMOR
英文摘要:

This study retrospectively collected the clinical and laboratory data of 114 patients with Castleman disease (CD) from a single medical centre. Clinical classification identified 62 patients (544%) with unicentric Castleman disease and 52 (456%) with multi-centric Castleman disease. Pathological classification revealed 68 cases (596%) of hyaline vascular variant, 16 (141%) mixed cellular variant (Mix) and 30 (263%) plasmacytic variant. Clinical complications occurred in 69 CD patients, including 37 cases of paraneoplastic pemphigus (PNP) and 25 cases with renal complications. Haematological involvement, pleural effusion and/or ascites and POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) were also found. Univariate analysis showed that presence of clinical complications and PNP were both risk factors relating to CD patient survival. Prognostic factors showing P<015 in univariate analysis and those with clinical significance were subjected to multivariate analysis using a Cox regression model. PNP presence and age over 40years both significantly adversely affected survival. Thus, only presence of PNP was identified as an independent unfavourable survival risk factor in both univariate and multivariate analyses. Overall, the present data provide a panoramic description of CD cases and emphasize that the presence of PNP is an adverse prognostic factor.

语种: 英语
所属项目编号: 7143183
项目资助者: Beijing Natural Science Foundation, China
WOS记录号: WOS:000355657300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57680
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Peking Univ, Dept Haematol, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Dept Pathol, Hosp 1, Beijing 100034, Peoples R China
4.Peking Univ, Dept Biostat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Dong, Yujun,Wang, Mingyue,Nong, Lin,et al. Clinical and laboratory characterization of 114 cases of Castleman disease patients from a single centre: paraneoplastic pemphigus is an unfavourable prognostic factor[J]. BRITISH JOURNAL OF HAEMATOLOGY,2015,169(6):834-842.
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