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学科主题: 临床医学
题名:
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer
作者: Chen, Lei; Jiang, Beihai; Wang, Zaozao; Liu, Maoxing; Ma, Yiyuan; Yang, Hong; Xing, Jiadi; Zhang, Chenghai; Yao, Zhendan; Zhang, Nan; Cui, Ming; Su, Xiangqian
关键词: GATA2 ; Colorectal cancer ; Prognosis
刊名: MEDICAL ONCOLOGY
发表日期: 2013-06-01
DOI: 10.1007/s12032-013-0498-7
卷: 30, 期:2
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TRANSCRIPTION FACTOR ; MYELOID-LEUKEMIA ; COLON-CANCER ; MUTATIONS ; SURVIVAL ; CETUXIMAB ; RECEPTOR ; GENDER ; COHORT ; GENES
英文摘要:

GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types of cancer. However, the expression and prognostic significance of GATA2 in colorectal cancer remain unknown. In this study, GATA2 protein expression was examined using immunohistochemistry in 307 colorectal cancer tissues, and its association with clinicopathological features and prognosis was analyzed. The expression of GATA2 was found to be significantly higher in colorectal cancer tissues than in matched adjacent noncancerous tissues (60.3 vs. 9.0 %, P < 0.0001). The expression of GATA2 was significantly correlated with tumor location (P = 0.005), histological type (P = 0.019), and recurrence (P = 0.009). Kaplan-Meier survival analysis demonstrated that patients with high levels of GATA2 expression had worse disease-free survival outcomes than those with low levels of GATA2 expression (P = 0.016). Univariate analysis showed high levels of GATA2 expression to be significantly associated with shorter periods of disease-free survival (HR 2.196; 95 % CI 1.142-4.226; P = 0.018). Multivariate analysis showed GATA2 expression to be an independent prognostic factor for patients with colorectal cancer (HR 1.952; 95 % CI 1.010-3.775; P = 0.047). These findings suggest that high levels of GATA2 expression may be a useful indicator of disease recurrence after curative colorectal cancer treatment.

语种: 英语
所属项目编号: 81272766 ; 81071658 ; 2009-2093 ; Z121107001012130 ; 7132054 ; 2011060 ; 2007AA021103
项目资助者: National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing ; National 863 Program
WOS记录号: WOS:000319450400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57684
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: Peking Univ Canc Hosp & Inst, Dept Minimally Invas Gastrointestinal Surg, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China

Recommended Citation:
Chen, Lei,Jiang, Beihai,Wang, Zaozao,et al. Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer[J]. MEDICAL ONCOLOGY,2013,30(2).
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