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学科主题临床医学
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer
Chen, Lei; Jiang, Beihai; Wang, Zaozao; Liu, Maoxing; Ma, Yiyuan; Yang, Hong; Xing, Jiadi; Zhang, Chenghai; Yao, Zhendan; Zhang, Nan; Cui, Ming; Su, Xiangqian
关键词Gata2 Colorectal Cancer Prognosis
刊名MEDICAL ONCOLOGY
2013-06-01
DOI10.1007/s12032-013-0498-7
30期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TRANSCRIPTION FACTOR ; MYELOID-LEUKEMIA ; COLON-CANCER ; MUTATIONS ; SURVIVAL ; CETUXIMAB ; RECEPTOR ; GENDER ; COHORT ; GENES
英文摘要

GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types of cancer. However, the expression and prognostic significance of GATA2 in colorectal cancer remain unknown. In this study, GATA2 protein expression was examined using immunohistochemistry in 307 colorectal cancer tissues, and its association with clinicopathological features and prognosis was analyzed. The expression of GATA2 was found to be significantly higher in colorectal cancer tissues than in matched adjacent noncancerous tissues (60.3 vs. 9.0 %, P < 0.0001). The expression of GATA2 was significantly correlated with tumor location (P = 0.005), histological type (P = 0.019), and recurrence (P = 0.009). Kaplan-Meier survival analysis demonstrated that patients with high levels of GATA2 expression had worse disease-free survival outcomes than those with low levels of GATA2 expression (P = 0.016). Univariate analysis showed high levels of GATA2 expression to be significantly associated with shorter periods of disease-free survival (HR 2.196; 95 % CI 1.142-4.226; P = 0.018). Multivariate analysis showed GATA2 expression to be an independent prognostic factor for patients with colorectal cancer (HR 1.952; 95 % CI 1.010-3.775; P = 0.047). These findings suggest that high levels of GATA2 expression may be a useful indicator of disease recurrence after curative colorectal cancer treatment.

语种英语
WOS记录号WOS:000319450400007
项目编号81272766 ; 81071658 ; 2009-2093 ; Z121107001012130 ; 7132054 ; 2011060 ; 2007AA021103
资助机构National Natural Science Foundation of China ; Capital Medical Development and Research Foundation ; Clinical Characteristics and Application Research of Capital ; Beijing Natural Science Foundation ; New Star of Science and Technology Program of Beijing ; National 863 Program
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57684
专题北京大学临床肿瘤学院_胃肠肿瘤中心
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
北京大学临床肿瘤学院_生化与分子生物学研究室
北京大学临床肿瘤学院_骨、微创外科
北京大学临床肿瘤学院_护理部
作者单位Peking Univ Canc Hosp & Inst, Dept Minimally Invas Gastrointestinal Surg, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Chen, Lei,Jiang, Beihai,Wang, Zaozao,et al. Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer[J]. MEDICAL ONCOLOGY,2013,30(2).
APA Chen, Lei.,Jiang, Beihai.,Wang, Zaozao.,Liu, Maoxing.,Ma, Yiyuan.,...&Su, Xiangqian.(2013).Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer.MEDICAL ONCOLOGY,30(2).
MLA Chen, Lei,et al."Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer".MEDICAL ONCOLOGY 30.2(2013).
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