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学科主题临床医学
Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China
Wei, Yidong1; Guo, Huixin1; The, Erlinda1; Che, Wenliang1; Shen, Jianying1; Hou, Lei1; Zhao, Shuiping2; Ye, Ping3; Li, Gang1; Wang, Dongzhi1; Jie, Qiqiang1; Hu, Dayi4
关键词Coronary Artery Disease Diabetes Mellitus Statins Dyslipidemia
刊名INTERNATIONAL JOURNAL OF CARDIOLOGY
2015-03-01
DOI10.1016/j.ijcard.2015.01.024
182页:469-475
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者National Natural Science Funds of China ; Merck Co., Inc. ; National Natural Science Funds of China ; Merck Co., Inc.
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]CARDIOVASCULAR RISK-FACTORS ; HEART-DISEASE ; SECONDARY PREVENTION ; POOLED ANALYSIS ; DYSLIPIDEMIA ; PREVALENCE ; GUIDELINES ; MANAGEMENT ; MORTALITY ; THERAPY
英文摘要

Background: We evaluate the prevalence of persistent lipid abnormalities and statin use in Chinese coronary artery disease patients with and without diabetes.

Methods and results: In this cross-sectional observational study, 8965 outpatients from 200 clinical departments of 122 hospitals in 27 provinces nationwide of China who had coronary artery disease and were taking a statin were consecutively enrolled and divided into two groups based on diabetes status. The European Society of Cardiology/European Arthrosclerosis Society Guidelines for the management of dyslipidemias and the Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults were used to compare the control rates of low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides (TG). Among the 8965 participants, 33.3% had been diagnosed with diabetes mellitus. According to the ESC Guidelines, the percentage of patients with not at goal LDL cholesterol did not differ significantly between patients with diabetes and those without diabetes (71.9% vs. 72.7%, P=0.46). The percentages of patients with not-at-goal levels of HDL and TG were 42.9% vs. 34.4% (P < 0.001) and 39.1% vs. 34.3% (P < 0.001) among patients with diabetes and those without, respectively. Only approximately 10% of patients in both groups had optimal LDL-C, HDL-C, and TG levels. Compared with patients without diabetes, patients with diabetes were more likely to have mixed dyslipidemia. Atorvastatin (47.0%) and simvastatin (34.4%) were the two most frequently used statins, and the average statin dosage was 29.09 mg/day (simvastatin equivalent). Less than 1% of patients were treated with another lipid-lowering drug in combination with a statin.

Conclusions: Although international guidelines highly recommend intensive lipid modulation in patients with coronary artery disease, persistent dyslipidemia is still prevalent among these patients in China, even with statin treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种英语
所属项目编号30800466 ; 81270193
资助者National Natural Science Funds of China ; Merck Co., Inc. ; National Natural Science Funds of China ; Merck Co., Inc.
WOS记录号WOS:000351927600129
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57686
专题北京大学第二临床医学院_心血管内科
作者单位1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei, Yidong,Guo, Huixin,The, Erlinda,et al. Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2015,182:469-475.
APA Wei, Yidong.,Guo, Huixin.,The, Erlinda.,Che, Wenliang.,Shen, Jianying.,...&Hu, Dayi.(2015).Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China.INTERNATIONAL JOURNAL OF CARDIOLOGY,182,469-475.
MLA Wei, Yidong,et al."Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China".INTERNATIONAL JOURNAL OF CARDIOLOGY 182(2015):469-475.
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