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学科主题: 临床医学
题名:
Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China
作者: Wei, Yidong1; Guo, Huixin1; The, Erlinda1; Che, Wenliang1; Shen, Jianying1; Hou, Lei1; Zhao, Shuiping2; Ye, Ping3; Li, Gang1; Wang, Dongzhi1; Jie, Qiqiang1; Hu, Dayi4
关键词: Coronary artery disease ; Diabetes mellitus ; Statins ; Dyslipidemia
刊名: INTERNATIONAL JOURNAL OF CARDIOLOGY
发表日期: 2015-03-01
DOI: 10.1016/j.ijcard.2015.01.024
卷: 182, 页:469-475
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: CARDIOVASCULAR RISK-FACTORS ; HEART-DISEASE ; SECONDARY PREVENTION ; POOLED ANALYSIS ; DYSLIPIDEMIA ; PREVALENCE ; GUIDELINES ; MANAGEMENT ; MORTALITY ; THERAPY
英文摘要:

Background: We evaluate the prevalence of persistent lipid abnormalities and statin use in Chinese coronary artery disease patients with and without diabetes.

Methods and results: In this cross-sectional observational study, 8965 outpatients from 200 clinical departments of 122 hospitals in 27 provinces nationwide of China who had coronary artery disease and were taking a statin were consecutively enrolled and divided into two groups based on diabetes status. The European Society of Cardiology/European Arthrosclerosis Society Guidelines for the management of dyslipidemias and the Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults were used to compare the control rates of low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triglycerides (TG). Among the 8965 participants, 33.3% had been diagnosed with diabetes mellitus. According to the ESC Guidelines, the percentage of patients with not at goal LDL cholesterol did not differ significantly between patients with diabetes and those without diabetes (71.9% vs. 72.7%, P=0.46). The percentages of patients with not-at-goal levels of HDL and TG were 42.9% vs. 34.4% (P < 0.001) and 39.1% vs. 34.3% (P < 0.001) among patients with diabetes and those without, respectively. Only approximately 10% of patients in both groups had optimal LDL-C, HDL-C, and TG levels. Compared with patients without diabetes, patients with diabetes were more likely to have mixed dyslipidemia. Atorvastatin (47.0%) and simvastatin (34.4%) were the two most frequently used statins, and the average statin dosage was 29.09 mg/day (simvastatin equivalent). Less than 1% of patients were treated with another lipid-lowering drug in combination with a statin.

Conclusions: Although international guidelines highly recommend intensive lipid modulation in patients with coronary artery disease, persistent dyslipidemia is still prevalent among these patients in China, even with statin treatment. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 30800466 ; 81270193
项目资助者: National Natural Science Funds of China ; Merck Co., Inc.
WOS记录号: WOS:000351927600129
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57686
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Wei, Yidong,Guo, Huixin,The, Erlinda,et al. Persistent lipid abnormalities in statin-treated coronary artery disease patients with and without diabetes in China[J]. INTERNATIONAL JOURNAL OF CARDIOLOGY,2015,182:469-475.
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