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学科主题临床医学
Stimulating beta cell replication and improving islet graft function by GPR119 agonists
Gao, Jie1,2,3; Tian, Lei1,2,4; Weng, Guobin1,2,5; Bhagroo, Nicholas V.6; Sorenson, Robert L.6; O′ Brien, Timothy D.7; Luo, Jian8; Guo, Zhiguang1,2
关键词Glp-1 Gpr119 Islet Graft Function Islet Transplantation Beta-cell Regeneration Beta-cell Replication
刊名TRANSPLANT INTERNATIONAL
2011-11-01
DOI10.1111/j.1432-2277.2011.01332.x
24期:11页:1124-1134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]GLUCAGON-LIKE PEPTIDE-1 ; PROTEIN-COUPLED RECEPTOR ; DIABETIC NOD MICE ; GLYCEMIC CONTROL ; IMMUNOSUPPRESSIVE REGIMEN ; SINGLE-DONOR ; TRANSPLANTATION ; PROLIFERATION ; SECRETION ; GROWTH
英文摘要

G protein-coupled receptor 119 (GPR119) is predominantly expressed in beta cells and intestinal L cells. In this study, we investigated whether oleoylethanolamide (OEA), a GPR119 endogenous ligand, and PSN632408, a GPR119 synthetic agonist, can stimulate beta-cell replication in vitro and in vivo and improve islet graft function in diabetic mice. We found that OEA and PSN632408 significantly increased numbers of insulin(+)/5-bromo-2′-deoxyuridine (BrdU)(+) beta cells in cultured mouse islets in a dose-dependent manner. All diabetic recipient mice, given marginal syngeneic islet transplants with OEA or PSN632408 or vehicle, achieved normoglycemia at 4 weeks after transplantation. However, normoglycemia was achieved significantly faster in OEA- or PSN632408-treated diabetic mice than in vehicle-treated diabetic mice (P < 0.05). The percentage of insulin(+)/BrdU(+) beta cells in islet grafts in OEA- and PSN632408-treated mice was significantly higher than in vehicle-treated mice (P < 0.01). Our data demonstrated that OEA and PSN632408 can stimulate beta-cell replication in vitro and in vivo and improve islet graft function. Targeting GPR119 is a novel therapeutic approach to increase beta-cell mass and to improve islet graft function by stimulating beta-cell replication.

语种英语
WOS记录号WOS:000295835500015
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57695
专题北京大学第二临床医学院_肝胆外科
作者单位1.NGM Biopharmaceut Inc, San Francisco, CA USA
2.Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA
3.Univ Minnesota, Schulze Diabet Inst, Minneapolis, MN 55455 USA
4.Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100871, Peoples R China
5.Guangxi Med Univ, Affiliated Hosp 1, Dept Surg, Nanning, Peoples R China
6.Ningbo Univ, Yinzhou Hosp 2, Dept Urol, Ningbo 315211, Zhejiang, Peoples R China
7.Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN USA
8.Univ Minnesota, Dept Vet Populat Med, Minneapolis, MN USA
推荐引用方式
GB/T 7714
Gao, Jie,Tian, Lei,Weng, Guobin,et al. Stimulating beta cell replication and improving islet graft function by GPR119 agonists[J]. TRANSPLANT INTERNATIONAL,2011,24(11):1124-1134.
APA Gao, Jie.,Tian, Lei.,Weng, Guobin.,Bhagroo, Nicholas V..,Sorenson, Robert L..,...&Guo, Zhiguang.(2011).Stimulating beta cell replication and improving islet graft function by GPR119 agonists.TRANSPLANT INTERNATIONAL,24(11),1124-1134.
MLA Gao, Jie,et al."Stimulating beta cell replication and improving islet graft function by GPR119 agonists".TRANSPLANT INTERNATIONAL 24.11(2011):1124-1134.
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