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学科主题: 药学
题名:
Semi-synthesis of neomangiferin from mangiferin
作者: Wei, Xiong; Liang, Danlin; Ning, Maoheng; Wang, Qing; Meng, Xiangbao; Li, Zhongjun
关键词: Neomangiferin ; Semi-synthesis ; Regioselective protection ; Glycosylation ; Carbohydrate
刊名: TETRAHEDRON LETTERS
发表日期: 2014-05-07
DOI: 10.1016/j.tetlet.2014.03.129
卷: 55, 期:19, 页:3083-3086
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: NATURALLY-OCCURRING XANTHONES ; SELECTIVE DEPROTECTION ; BAICALEIN DERIVATIVES ; AROMATIC ACETATES ; NATURAL-PRODUCTS ; ONE-POT ; MILD ; ALKYLATION ; GLUCOSIDE ; CATALYST
英文摘要:

Neomangiferin, a natural xanthone derivative bearing both O- and C-glucosides, was isolated from the leaves of Gentiana asclepiadea L and has shown potential anti-diabetic activity. We describe herein the first semi-synthesis of neomangiferin from the natural C-glucoside mangiferin and glucose. The developed synthesis presents a facile protection strategy using Jurd′s method to distinguish the different phenolic hydroxyl groups. Following this strategy, the regioselective protection of 1,3,6-hydroxyl groups was accomplished and neomangiferin was prepared by glycosylation under the phase-transfer catalysis conditions. (c) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012CB822100 ; 2012ZX09502001-001 ; 21232002 ; 21072016 ; 21072017 ; 20130001110058
项目资助者: National Basic Research Program of China (973 Program) ; National Key Technology R&amp ; D Program &prime ; New Drug Innovation&prime ; of China ; National Natural Science Foundation of China (NSFC) ; National Research Foundation for the Doctoral Program of Higher Education of China
WOS记录号: WOS:000336115000018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57698
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wei, Xiong,Liang, Danlin,Ning, Maoheng,et al. Semi-synthesis of neomangiferin from mangiferin[J]. TETRAHEDRON LETTERS,2014,55(19):3083-3086.
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