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Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine
Zhang, Zhili1; Liu, Jie1; Liu, Weidong1; Wang, Xiaowei1; Cheng, Zhijian3; Liu, Junyi1,2
刊名JOURNAL OF HETEROCYCLIC CHEMISTRY
2009-11-01
DOI10.1002/jhet.197
46期:6页:1151-1153
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]THYMIDYLATE SYNTHETASE ; ANALOG ; INHIBITOR ; ACID
英文摘要

The synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine 3 is described from 2-amino-6-methyluracil 4 through the crucial step of 2-pivaloyl protecting and cyclization. The assignment of the structure of 3 was performed by its spectral data, the (1)H NMR, (13)C NMR, gHMQC, and HRMS spectra.

语种英语
WOS记录号WOS:000272878500012
项目编号20672008
资助机构National Sciences Foundation of China ; 985 Program of Ministry of Education of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57699
专题北京大学药学院_化学生物学系
作者单位1.Coll Jiujiang, Dept Chem, Jiujiang 33200, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Zhili,Liu, Jie,Liu, Weidong,et al. Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY,2009,46(6):1151-1153.
APA Zhang, Zhili,Liu, Jie,Liu, Weidong,Wang, Xiaowei,Cheng, Zhijian,&Liu, Junyi.(2009).Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine.JOURNAL OF HETEROCYCLIC CHEMISTRY,46(6),1151-1153.
MLA Zhang, Zhili,et al."Synthesis of 2-Amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d]pyrimidine from 2-Amino-4-hydroxyl-6-methylpyrimidine".JOURNAL OF HETEROCYCLIC CHEMISTRY 46.6(2009):1151-1153.
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