IR@PKUHSC  > 北京大学口腔医学院  > 口腔生物研究室
Shammah - induced oral leukoplakia-like lesions
Zhang, X; Schmitz, W; Gelderblom, HR; Reichart, PA
关键词Algeria Leukoplakia Oral Precancer Snuff Tobacco
WOS标题词Science & Technology
类目[WOS]Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]Oncology ; Dentistry, Oral Surgery & Medicine

A Shammah-induced oral leukoplakia-like lesion is described in a 44-year-old Algerian patient, who used this specific chewing tobacco since 33 years. The extended white lesion was located to the right mandibular vestibule and had a homogeneous appearance. Shammah is a chewing tobacco consisting of powdered tobacco leaves with carbonate of lime and other substances. It has been associated with oral cancer in Saudi Arabia. Histologically, acanthosis, hyperortho- and parakeratosis were seen. The spinous cell layer showed large pale staining epithelial cells with pycnotic nuclei. Atypia was not observed, however, an increase in mitotic activity was apparent. The subepithelial infiltrate was mild. Electron microscopy showed changes in the basal membrane with interruptions, duplications and triplications. Follow-up of the patient for 2 years revealed that, whenever, the patient changed the location of application, the white lesion regressed or disappeared within 4-6 weeks. Due to the composition of Shammah, the lesion induced has features of a mucosal burn. In contrast to other smokeless tobacco variants, Shammah seems to cause changes which, according to the small number of reports, may transform into oral cancer. As such, Shammah-induced oral leukoplakia-like lesions may be considered precancerous. (C) 2001 Elsevier Science Ltd. All rights reserved.

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作者单位1.Robert Koch Inst, D-13353 Berlin, Germany
2.Charite Univ Klinikum, Zentrum Zahnmed, Abt Oralchirurg & Zahnarztliche Rontgenol, D-13353 Berlin, Germany
3.Beijing Med Univ, Inst Stomatol, Dept Oral Biol, Haidian Weigongcun, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Zhang, X,Schmitz, W,Gelderblom, HR,et al. Shammah - induced oral leukoplakia-like lesions[J]. ORAL ONCOLOGY,2001,37(7):609-612.
APA Zhang, X,Schmitz, W,Gelderblom, HR,&Reichart, PA.(2001).Shammah - induced oral leukoplakia-like lesions.ORAL ONCOLOGY,37(7),609-612.
MLA Zhang, X,et al."Shammah - induced oral leukoplakia-like lesions".ORAL ONCOLOGY 37.7(2001):609-612.
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