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IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers
作者: Deng, Dajun; Liu, Zhaojun; Du, Yantao; Herceg, Z; Ushijima, T
刊名: EPIGENETICS AND CANCER, PT B
发表日期: 2010
DOI: 10.1016/S0065-2660(10)71005-1
卷: 71, 页:125-176
收录类别: BSCI ; SCI
文章类型: Book Chapter
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity
研究领域[WOS]: Genetics & Heredity
关键词[WOS]: CELL LUNG-CANCER ; ISLAND METHYLATOR PHENOTYPE ; HUMAN HEPATOCELLULAR-CARCINOMA ; TUMOR-SUPPRESSOR GENE ; EPITHELIAL OVARIAN-CANCER ; MICRORNA EXPRESSION PROFILES ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; MLH1 PROMOTER METHYLATION ; CHRONIC MYELOID-LEUKEMIA ; HUMAN GASTRIC-CARCINOMA
英文摘要:

Alterations of DNA methylation and transcription of microRNAs (miRNAs) are very stable phenomena in tissues and body fluids and suitable for sensitive detection. These advantages enable us to translate some important discoveries on epigenetic oncology into biomarkers for control of cancer. A few promising epigenetic biomarkers are emerging. Clinical trials using methylated CpG islands of p16, Septin9, and MGMT as biomarkers are carried out for predication of cancer development, diagnosis, and chemosensitivity. Circulating miRNAs are promising biomarkers, too. Breakthroughs in the past decade imply that epigenetic biomarkers may be useful in reducing the burden of cancer. (C) 2010, Elsevier Inc.

语种: 英语
WOS记录号: WOS:000303839000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57724
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Deng, Dajun,Liu, Zhaojun,Du, Yantao,et al. Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers[J]. EPIGENETICS AND CANCER, PT B,2010,71:125-176.
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