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学科主题临床医学
Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers
Deng, Dajun; Liu, Zhaojun; Du, Yantao; Herceg, Z; Ushijima, T
刊名EPIGENETICS AND CANCER, PT B
2010
DOI10.1016/S0065-2660(10)71005-1
71页:125-176
收录类别BSCI ; SCI
文章类型Book Chapter
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity
研究领域[WOS]Genetics & Heredity
关键词[WOS]CELL LUNG-CANCER ; ISLAND METHYLATOR PHENOTYPE ; HUMAN HEPATOCELLULAR-CARCINOMA ; TUMOR-SUPPRESSOR GENE ; EPITHELIAL OVARIAN-CANCER ; MICRORNA EXPRESSION PROFILES ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; MLH1 PROMOTER METHYLATION ; CHRONIC MYELOID-LEUKEMIA ; HUMAN GASTRIC-CARCINOMA
英文摘要

Alterations of DNA methylation and transcription of microRNAs (miRNAs) are very stable phenomena in tissues and body fluids and suitable for sensitive detection. These advantages enable us to translate some important discoveries on epigenetic oncology into biomarkers for control of cancer. A few promising epigenetic biomarkers are emerging. Clinical trials using methylated CpG islands of p16, Septin9, and MGMT as biomarkers are carried out for predication of cancer development, diagnosis, and chemosensitivity. Circulating miRNAs are promising biomarkers, too. Breakthroughs in the past decade imply that epigenetic biomarkers may be useful in reducing the burden of cancer. (C) 2010, Elsevier Inc.

语种英语
WOS记录号WOS:000303839000005
引用统计
被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57724
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_病因学研究室
作者单位Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Deng, Dajun,Liu, Zhaojun,Du, Yantao,et al. Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers[J]. EPIGENETICS AND CANCER, PT B,2010,71:125-176.
APA Deng, Dajun,Liu, Zhaojun,Du, Yantao,Herceg, Z,&Ushijima, T.(2010).Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers.EPIGENETICS AND CANCER, PT B,71,125-176.
MLA Deng, Dajun,et al."Epigenetic Alterations as Cancer Diagnostic, Prognostic, and Predictive Biomarkers".EPIGENETICS AND CANCER, PT B 71(2010):125-176.
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