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学科主题: 药学
题名:
Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents
作者: Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
关键词: 4,5-Dichloro-3(2H)-pyridazinone ; 4-Chloro-5-methoxy-3(2H)-pyridazinone ; beta-Trifluoroethylation ; Oxonium ; Methyl group migration ; Alkylation
刊名: MOLECULES
发表日期: 2009-02-01
DOI: 10.3390/molecules14020777
卷: 14, 期:2, 页:777-784
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: ANTIARRHYTHMICS
英文摘要:

To synthesize 4-chloro-5-methoxy-2-(beta-trifluoroethyl)-3(2H)-pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH(2)CF(3) (R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methoxy-2- methyl-3(2H)-pyridazinone (7) and 4-chloro-2-methyl-5-(beta-trifluoroethoxy)-3(2)-pyridazinone (8).

语种: 英语
WOS记录号: WOS:000263823400014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57727
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Li, Qin,Lin, Guichun,Liu, Li,et al. Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents[J]. MOLECULES,2009,14(2):777-784.
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