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Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents
Li, Qin; Lin, Guichun; Liu, Li; Yang, Zhenjun; Zhang, Li-He
关键词4-chloro-5-methoxy-3(2h)-pyridazinone 4 Beta-trifluoroethylation 5-dichloro-3(2h)-pyridazinone Oxonium Methyl Group Migration Alkylation
刊名MOLECULES
2009-02-01
DOI10.3390/molecules14020777
14期:2页:777-784
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]ANTIARRHYTHMICS
英文摘要

To synthesize 4-chloro-5-methoxy-2-(beta-trifluoroethyl)-3(2H)-pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH(2)CF(3) (R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methoxy-2- methyl-3(2H)-pyridazinone (7) and 4-chloro-2-methyl-5-(beta-trifluoroethoxy)-3(2)-pyridazinone (8).

语种英语
WOS记录号WOS:000263823400014
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57727
专题北京大学药学院
北京大学药学院_药物化学系
北京大学第一临床医学院_药剂科
北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Qin,Lin, Guichun,Liu, Li,et al. Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents[J]. MOLECULES,2009,14(2):777-784.
APA Li, Qin,Lin, Guichun,Liu, Li,Yang, Zhenjun,&Zhang, Li-He.(2009).Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents.MOLECULES,14(2),777-784.
MLA Li, Qin,et al."Methyl Carbonium Ion Migration during the Reaction of 4-Chloro-5-methoxyl-3(2H)-pyridazinone with Trifluoroethylation Agents".MOLECULES 14.2(2009):777-784.
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