北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 药剂学系  > 期刊论文
学科主题: 药学
题名:
Preparation and characterization of ketoprofen-loaded microspheres for embolization
作者: Zhou, Chao; Cui, Daichao; Zhang, Yuan; Yuan, Huiyan; Fan, Tianyuan
刊名: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
发表日期: 2012-02-01
DOI: 10.1007/s10856-011-4492-3
卷: 23, 期:2, 页:409-418
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: UTERINE ARTERY EMBOLIZATION ; POLYVINYL-ALCOHOL PARTICLES ; ACRYL GELATIN MICROSPHERES ; IN-VITRO EVALUATION ; DRUG ELUTING BEADS ; TRANSARTERIAL CHEMOEMBOLIZATION ; THERAPEUTIC EMBOLIZATION ; DC BEAD ; RELEASE ; PAIN
英文摘要:

To deliver drug locally and relieve the syndrome of pain after uterine artery embolization, N-[tris (hydroxymethyl) methyl] acrylamide-gelatin microspheres were prepared based on inverse suspension polymerization and then separated into a number of subgroups (150-350, 350-560, 560-710, 710-1,000, and 1,000-1,430 mu m) by wet-sieving. The microspheres were dried by lyophilization or by washing with anhydrous ethanol. And ketoprofen was loaded by soaking dried blank microspheres into concentrated ketoprofen ethanol solution. The ketoprofen loading level in different subgroups of microspheres was measured and found higher when the microspheres were dried by lyophilization. Equilibrium water content and mean diameters of microspheres decreased after drug loading, especially in subgroups with larger size. The microspheres went through the catheter without any difficulty. Compression and relaxation tests were performed on microspheres before lyophilization, embosphere (TM), microspheres after lyophilization and ketoprofen loading microspheres. The Young′s moduli were 54.74, 64.19, 98.15, and 120.44 kPa, respectively. The release of ketoprofen from microspheres in different subgroups was studied by using the USPII method and T-cell apparatus, respectively. The results indicate that the release rate of ketoprofen depends upon the diameter of microspheres, the type of dissolution apparatus and the flow rate of media in the case that T-cell apparatus was applied. The CH50 test shows that the activation of complement by ketoprofen-loaded micro-spheres was lower than by blank ones.

语种: 英语
所属项目编号: 2009ZX09310-001
项目资助者: State Key Projects
WOS记录号: WOS:000301640800021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57732
Appears in Collections:北京大学药学院_药剂学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhou, Chao,Cui, Daichao,Zhang, Yuan,et al. Preparation and characterization of ketoprofen-loaded microspheres for embolization[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2012,23(2):409-418.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Chao]'s Articles
[Cui, Daichao]'s Articles
[Zhang, Yuan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Chao]‘s Articles
[Cui, Daichao]‘s Articles
[Zhang, Yuan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace