IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
Preparation and characterization of ketoprofen-loaded microspheres for embolization
Zhou, Chao; Cui, Daichao; Zhang, Yuan; Yuan, Huiyan; Fan, Tianyuan
刊名JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
2012-02-01
DOI10.1007/s10856-011-4492-3
23期:2页:409-418
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
资助者State Key Projects ; State Key Projects
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]UTERINE ARTERY EMBOLIZATION ; POLYVINYL-ALCOHOL PARTICLES ; ACRYL GELATIN MICROSPHERES ; IN-VITRO EVALUATION ; DRUG ELUTING BEADS ; TRANSARTERIAL CHEMOEMBOLIZATION ; THERAPEUTIC EMBOLIZATION ; DC BEAD ; RELEASE ; PAIN
英文摘要

To deliver drug locally and relieve the syndrome of pain after uterine artery embolization, N-[tris (hydroxymethyl) methyl] acrylamide-gelatin microspheres were prepared based on inverse suspension polymerization and then separated into a number of subgroups (150-350, 350-560, 560-710, 710-1,000, and 1,000-1,430 mu m) by wet-sieving. The microspheres were dried by lyophilization or by washing with anhydrous ethanol. And ketoprofen was loaded by soaking dried blank microspheres into concentrated ketoprofen ethanol solution. The ketoprofen loading level in different subgroups of microspheres was measured and found higher when the microspheres were dried by lyophilization. Equilibrium water content and mean diameters of microspheres decreased after drug loading, especially in subgroups with larger size. The microspheres went through the catheter without any difficulty. Compression and relaxation tests were performed on microspheres before lyophilization, embosphere (TM), microspheres after lyophilization and ketoprofen loading microspheres. The Young′s moduli were 54.74, 64.19, 98.15, and 120.44 kPa, respectively. The release of ketoprofen from microspheres in different subgroups was studied by using the USPII method and T-cell apparatus, respectively. The results indicate that the release rate of ketoprofen depends upon the diameter of microspheres, the type of dissolution apparatus and the flow rate of media in the case that T-cell apparatus was applied. The CH50 test shows that the activation of complement by ketoprofen-loaded micro-spheres was lower than by blank ones.

语种英语
所属项目编号2009ZX09310-001
资助者State Key Projects ; State Key Projects
WOS记录号WOS:000301640800021
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57732
Collection北京大学药学院_药剂学系
作者单位Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Chao,Cui, Daichao,Zhang, Yuan,et al. Preparation and characterization of ketoprofen-loaded microspheres for embolization[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2012,23(2):409-418.
APA Zhou, Chao,Cui, Daichao,Zhang, Yuan,Yuan, Huiyan,&Fan, Tianyuan.(2012).Preparation and characterization of ketoprofen-loaded microspheres for embolization.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,23(2),409-418.
MLA Zhou, Chao,et al."Preparation and characterization of ketoprofen-loaded microspheres for embolization".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 23.2(2012):409-418.
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