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学科主题基础医学
Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?
Chen, YY; Sun, RH; Han, WL; Zhang, YM; Song, QS; Di, CH; Ma, DL
关键词TF-1 cell apoptosis related gene-19 programmed cell death 5 nuclear translocation apoptosis
刊名FEBS LETTERS
2001-12-07
509期:2页:191-196
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]NUCLEOCYTOPLASMIC TRANSPORT ; CELL-LINE ; CASPASES ; ANTIBODY ; DNA
英文摘要

The programmed cell death 5 (PDCD5) protein is a novel protein related to regulation of cell apoptosis. In this report, we demonstrate that the level of PDCD5 protein expressed in cells undergoing apoptosis is significantly increased compared with normal cells, then the protein translocates rapidly from the cytoplasm to the nucleus of cells. The appearance of PDCD5 in the nuclei of apoptotic cells precedes the externalization of phosphatidylserine and fragmentation of chromosome DNA. This phenomenon is parallel to the loss of mitochondrial membrane potential, independent of the feature of apoptosis-inducing stimuli and also independent of the cell types and the apoptosis modality. In conclusion, the nuclear translocation of PDCD5 is a universal earlier event of the apoptotic process, and may be a novel early marker for apoptosis. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000172757500010
Citation statistics
Cited Times:77[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57734
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Chen, YY,Sun, RH,Han, WL,et al. Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?[J]. FEBS LETTERS,2001,509(2):191-196.
APA Chen, YY.,Sun, RH.,Han, WL.,Zhang, YM.,Song, QS.,...&Ma, DL.(2001).Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?.FEBS LETTERS,509(2),191-196.
MLA Chen, YY,et al."Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?".FEBS LETTERS 509.2(2001):191-196.
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