北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?
作者: Chen, YY; Sun, RH; Han, WL; Zhang, YM; Song, QS; Di, CH; Ma, DL
关键词: TF-1 cell apoptosis related gene-19 ; programmed cell death 5 ; nuclear translocation ; apoptosis
刊名: FEBS LETTERS
发表日期: 2001-12-07
卷: 509, 期:2, 页:191-196
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: NUCLEOCYTOPLASMIC TRANSPORT ; CELL-LINE ; CASPASES ; ANTIBODY ; DNA
英文摘要:

The programmed cell death 5 (PDCD5) protein is a novel protein related to regulation of cell apoptosis. In this report, we demonstrate that the level of PDCD5 protein expressed in cells undergoing apoptosis is significantly increased compared with normal cells, then the protein translocates rapidly from the cytoplasm to the nucleus of cells. The appearance of PDCD5 in the nuclei of apoptotic cells precedes the externalization of phosphatidylserine and fragmentation of chromosome DNA. This phenomenon is parallel to the loss of mitochondrial membrane potential, independent of the feature of apoptosis-inducing stimuli and also independent of the cell types and the apoptosis modality. In conclusion, the nuclear translocation of PDCD5 is a universal earlier event of the apoptotic process, and may be a novel early marker for apoptosis. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000172757500010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57734
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Chen_et_al-2001-FEBS_Letters.pdf(469KB)期刊论文出版稿限制开放 联系获取全文

作者单位: Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Chen, YY,Sun, RH,Han, WL,et al. Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?[J]. FEBS LETTERS,2001,509(2):191-196.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chen, YY]'s Articles
[Sun, RH]'s Articles
[Han, WL]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chen, YY]‘s Articles
[Sun, RH]‘s Articles
[Han, WL]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace