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学科主题: 临床医学
题名:
Association of Circulating Level of High Mobility Group Box 1 With Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis
作者: Wang, Chen; Gou, Shen-Ju; Chang, Dong-Yuan; Yu, Feng; Zhao, Ming-Hui; Chen, Min
刊名: ARTHRITIS CARE & RESEARCH
发表日期: 2013-11-01
DOI: 10.1002/acr.22187
卷: 65, 期:11, 页:1828-1834
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: SYSTEMIC-LUPUS-ERYTHEMATOSUS ; ANCA-ASSOCIATED VASCULITIS ; RENAL MANIFESTATIONS ; CHROMATIN PROTEIN ; IMMUNE-RESPONSES ; HMGB1 ; PATHOGENESIS ; INFLAMMATION ; GRANULOMATOSIS ; CYTOKINE
英文摘要:

ObjectiveHigh mobility group box 1 (HMGB-1), a kind of proinflammatory mediator, is associated with inflammatory conditions and tissue damage. Previous studies have reported that circulating HMGB-1 levels in patients with active antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) were associated with renal manifestations and burdens of granulomatous inflammation. The current study aimed to investigate whether circulating HMGB-1 levels were associated with disease activity in AAV.

MethodsPlasma samples from 74 patients with AAV in active stage and 65 patients with AAV in remission were collected. The plasma levels of HMGB-1 were determined by enzyme-linked immunosorbent assay. Associations between plasma levels of HMGB-1 with clinical and pathologic parameters were analyzed.

ResultsPlasma levels of HMGB-1 in active AAV patients were significantly higher than those in normal controls and AAV patients in remission (median 6.11 [interquartile range (IQR) 3.25-12.79] ng/ml versus median 1.12 [IQR 0.53-1.39] ng/ml, P< 0.001; median 6.11 [IQR 3.25-12.79] ng/ml versus median 3.04 [IQR 1.97-4.63] ng/ml, P < 0.001, respectively). Correlation analysis showed that plasma levels of HMGB-1 correlated with initial serum creatinine (r = 0.275, P = 0.018), estimated glomerular filtration rate (r = -0.277, P = 0.017), the Birmingham Vasculitis Activity Score (r = 0.308, P = 0.008), and C-reactive protein level (r = 0.309, P = 0.008). Among the patients with myeloperoxidase (MPO)-ANCA, those within the first quartile of plasma HMGB-1 levels had a significantly lower level of MPO-ANCA than those within the other 3 quartiles.

ConclusionCirculating HMGB-1 levels might reflect the disease activity and renal involvement of AAV vasculitis.

语种: 英语
所属项目编号: 2012CB517702 ; 20120001110018 ; 2011BAI10B04 ; 81300599
项目资助者: Chinese 973 Project ; Research Fund for the Doctoral Program of Higher Education of China ; National Key Technology Research and Development Program of the Ministry of Science and Technology of China ; National Natural Science Fund
WOS记录号: WOS:000326133600010
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57736
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Wang, Chen,Gou, Shen-Ju,Chang, Dong-Yuan,et al. Association of Circulating Level of High Mobility Group Box 1 With Disease Activity in Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis[J]. ARTHRITIS CARE &amp; RESEARCH,2013,65(11):1828-1834.
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