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Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration
Tao, Yong1,2; Libondi, Teodosio1,3; Jonas, Jost B.1
刊名JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
2010-02-01
DOI10.1089/jop.2009.0095
26期:1页:79-83
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology ; Pharmacology & Pharmacy
研究领域[WOS]Ophthalmology ; Pharmacology & Pharmacy
关键词[WOS]SUBFOVEAL CHOROIDAL NEOVASCULARIZATION ; AVASTIN ; RANIBIZUMAB ; EYES ; VERTEPORFIN ; THERAPY
英文摘要

Purpose: To analyze the long-term effect of multiple intravitreal injections of bevacizumab as therapy of exudative age-related macular degeneration (AMD).

Methods: The retrospective clinical interventional case series study included 45 patients (48 eyes) who received intravitreal injections of bevacizumab (1.5 mg) for treatment of exudative AMD and for whom the follow-up was >2 years. All patients received an initial series of 3 injections applied in intervals of 6-8 weeks. Subsequent injections were given in intervals ranging between 2 and 6 months. The mean number of all injections performed per eye was 8.6 +/- 2.5. The mean follow-up was 27.8 +/- 3.6 months. The main outcome parameters were best-corrected visual acuity (BCVA) and foveal thickness measurements by optical coherence tomography (OCT).

Results: Mean BCVA improved from 0.62 +/- 0.30 LogMAR at baseline to 0.55 +/- 0.28 LogMAR (P = 0.03) at 1 month after the 3 initial injections. At the end of follow-up, BCVA decreased significantly (P = 0.02) to 0.76 +/- 0.41 LogMAR. Bivariate correlation tests showed that the change in BCVA from baseline to the final examination at the end of follow-up was significantly associated only with the baseline BCVA (correlation coefficient r = 0.39, P = 0.006). The height of the subretinal fluid reduced significantly (P = 0.004) at 1 month after the 3 initial injections and remained so till the final follow-up (P = 0.01).

Conclusions: Multiple intravitreal bevacizumab injections initially led to an improvement in visual acuity, finally, however, failed to stabilize visual acuity after a follow-up of >2 years.

语种英语
WOS记录号WOS:000275047000010
资助机构Zeiss-Meditec Co. ; Heidelberg Engineering Co. ; German Academic Exchange Service (DAAD)
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57740
专题北京大学第二临床医学院_眼科
作者单位1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Univ Naples Federico 2, Dept Ophthalmol 2, I-80138 Naples, Italy
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GB/T 7714
Tao, Yong,Libondi, Teodosio,Jonas, Jost B.. Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration[J]. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,2010,26(1):79-83.
APA Tao, Yong,Libondi, Teodosio,&Jonas, Jost B..(2010).Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration.JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,26(1),79-83.
MLA Tao, Yong,et al."Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration".JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 26.1(2010):79-83.
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