北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration
作者: Tao, Yong1,2; Libondi, Teodosio1,3; Jonas, Jost B.1
刊名: JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
发表日期: 2010-02-01
DOI: 10.1089/jop.2009.0095
卷: 26, 期:1, 页:79-83
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology ; Pharmacology & Pharmacy
研究领域[WOS]: Ophthalmology ; Pharmacology & Pharmacy
关键词[WOS]: SUBFOVEAL CHOROIDAL NEOVASCULARIZATION ; AVASTIN ; RANIBIZUMAB ; EYES ; VERTEPORFIN ; THERAPY
英文摘要:

Purpose: To analyze the long-term effect of multiple intravitreal injections of bevacizumab as therapy of exudative age-related macular degeneration (AMD).

Methods: The retrospective clinical interventional case series study included 45 patients (48 eyes) who received intravitreal injections of bevacizumab (1.5 mg) for treatment of exudative AMD and for whom the follow-up was >2 years. All patients received an initial series of 3 injections applied in intervals of 6-8 weeks. Subsequent injections were given in intervals ranging between 2 and 6 months. The mean number of all injections performed per eye was 8.6 +/- 2.5. The mean follow-up was 27.8 +/- 3.6 months. The main outcome parameters were best-corrected visual acuity (BCVA) and foveal thickness measurements by optical coherence tomography (OCT).

Results: Mean BCVA improved from 0.62 +/- 0.30 LogMAR at baseline to 0.55 +/- 0.28 LogMAR (P = 0.03) at 1 month after the 3 initial injections. At the end of follow-up, BCVA decreased significantly (P = 0.02) to 0.76 +/- 0.41 LogMAR. Bivariate correlation tests showed that the change in BCVA from baseline to the final examination at the end of follow-up was significantly associated only with the baseline BCVA (correlation coefficient r = 0.39, P = 0.006). The height of the subretinal fluid reduced significantly (P = 0.004) at 1 month after the 3 initial injections and remained so till the final follow-up (P = 0.01).

Conclusions: Multiple intravitreal bevacizumab injections initially led to an improvement in visual acuity, finally, however, failed to stabilize visual acuity after a follow-up of >2 years.

语种: 英语
项目资助者: Zeiss-Meditec Co. ; Heidelberg Engineering Co. ; German Academic Exchange Service (DAAD)
WOS记录号: WOS:000275047000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57740
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Heidelberg, Med Fac Mannheim, Dept Ophthalmol, Heidelberg, Germany
2.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
3.Univ Naples Federico 2, Dept Ophthalmol 2, I-80138 Naples, Italy

Recommended Citation:
Tao, Yong,Libondi, Teodosio,Jonas, Jost B.. Long-Term Follow-Up After Multiple Intravitreal Bevacizumab Injections for Exudative Age-Related Macular Degeneration[J]. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,2010,26(1):79-83.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tao, Yong]'s Articles
[Libondi, Teodosio]'s Articles
[Jonas, Jost B.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tao, Yong]‘s Articles
[Libondi, Teodosio]‘s Articles
[Jonas, Jost B.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace