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Improving effect of post-treatment with Panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery
Yang, Ji-Ying2,3; Sun, Kai2; Wang, Chuan-She1,2; Guo, Jun2; Xue, Xin2; Liu, Yu-Ying2; Zheng, Jun2,3; Fan, Jing-Yu2; Liao, Fu-Long2; Han, Jing-Yan1,2
关键词Panax Notoginseng Saponins Microcirculatory Disturbance Leukocyte Adhesion Molecules Mast Cell Degranulation Lipopolysaccharide
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2008
DOI10.3233/CH-2008-1122
40期:2页:119-131
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]MURINE MAST-CELLS ; INFLAMMATORY CYTOKINES ; CARDIOTONIC PILLS ; SEVERE SEPSIS ; ACTIVATION ; THERAPY ; PERMEABILITY ; INDUCTION ; ADHESION ; DEGRANULATION
英文摘要

Panax notoginseng saponin (PNS) is the collective of the major effective components of Panax notoginseng. The present study intended to explore the effect of post-treatment of PNS on rat mesentery microcirculatory disturbance induced by lipopolysaccharide (LPS) continuous challenge. By virtue of a microcirculation observation system, the vascular hemodynamics were determined continuously until 60 min of LPS (2 mg/kg/h) infusion through the left femoral vein. After observation, blood was taken for assessment of the expression of CD11b/CD18 in neutrophils and the concentration of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interferon-gamma (INF-gamma) in plasma with flow-cytometry. The number of leukocytes adherent to venular wall, the intensity of hydrogen peroxide dependent dihydrorhodamine 123 (DHR) fluorescence in the venular walls and albumin leakage from venules were increased impressively after 20 min of LPS infusion, the RBCs velocity diminished after 30 min, and degranulated mast cells increased remarkably after 60 min. Post-treatment with PNS (5 mg/kg/h) through the left jugular vein from 20 min of LPS exposure resulted in significant reduction in the number of adherent leukocytes, degranulation of mast cell, expression of CD11b and the concentration of IL-6, INF-gamma, while had no influence on the intensity of DHR fluorescence and albumin leakage. The results suggested that post-treatment with PNS significantly attenuated microcirculatory disturbance induced by LPS.

语种英语
WOS记录号WOS:000261659500005
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57744
专题北京大学基础医学院
北京大学临床肿瘤学院_肾癌黑色素瘤内科
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
3.Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China
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GB/T 7714
Yang, Ji-Ying,Sun, Kai,Wang, Chuan-She,et al. Improving effect of post-treatment with Panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2008,40(2):119-131.
APA Yang, Ji-Ying.,Sun, Kai.,Wang, Chuan-She.,Guo, Jun.,Xue, Xin.,...&Han, Jing-Yan.(2008).Improving effect of post-treatment with Panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,40(2),119-131.
MLA Yang, Ji-Ying,et al."Improving effect of post-treatment with Panax notoginseng saponins on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 40.2(2008):119-131.
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