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学科主题: 临床医学
题名:
The impact of human herpesvirus 6B reactivation on early complications following allogeneic hematopoietic stem cell transplantation
作者: Wang, Li-Ru; Dong, Lu-Jia; Zhang, Mei-Jie; Lu, Dao-Pei
关键词: human herpesvirus 6 ; hematopoietic stem cell transplantation ; cytomegalovirus ; graft-versus-host disease ; hemorrhagic cystitis
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2006-10-01
DOI: 10.1016/j.bbmt.2006.06.001
卷: 12, 期:10, 页:1031-1037
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HUMAN-HERPESVIRUS-6 DNA ; HUMAN CYTOMEGALOVIRUS ; PLATELET ENGRAFTMENT ; PP65 ANTIGENEMIA ; LUNG-TISSUE ; VARIANT-B ; INFECTION ; BLOOD ; DISEASE
英文摘要:

Although human herpesvirus 6 (HHV-6) has been considered an important opportunistic and potentially fatal pathogen for allogeneic hematopoietic stem cell transplantation (HSCT), the clinical significance of HHV-6 reactivation remains controversial. In this study, we monitored HHV-6 DNAemia in 72 consecutive allogeneic HSCT recipients by real-time quantitative polymerase chain reaction. A total of 680 peripheral blood specimens were collected from the recipients before HSCT or at weekly intervals after HSCT. As the predominant variant, HHV-6B was detectable at least once in 47.2% (34/72) of HSCT recipients on the median day 21 (range, 7-84 days); HHV-6A reactivation occurred in only 1 recipient (1.4%). Detectable HHV-6B reactivation was associated with increased probability of skin rash by day 30 after HSCT (hazard ratio [HR], 3.68; 95% confidence interval [CI], 1.24-10.92; P = .019), cytomegalovirus (CMV) antigenemia (HR, 2.35; 95% CI, 1.32-4.19; P = .004), and hemorrhagic cystitis (HC) (HR, 2.59; 95% CI, 0.96-6.98; P = .061) by day 100 after HSCT. Neutrophil and platelet engraftment, mortality for 100 days after HSCT were not affected by HHV-6B reactivation. In conclusion, HHV-6 reactivation is a common event, and this study demonstrates a correlation between HHV-6B infection and CMV reactivation, early rash, and possibly increased incidence of HC after transplantation. (C) 2006 American Society for Blood and Marrow Transplantation.

语种: 英语
WOS记录号: WOS:000241305900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57746
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Dao Pei Hosp, Beijing, Peoples R China
3.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA

Recommended Citation:
Wang, Li-Ru,Dong, Lu-Jia,Zhang, Mei-Jie,et al. The impact of human herpesvirus 6B reactivation on early complications following allogeneic hematopoietic stem cell transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2006,12(10):1031-1037.
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