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学科主题: 精神卫生
题名:
Extract of Ginkgo biloba is equivalent to vitamin E in attenuating and preventing vacuous chewing movements in a rat model of tardive dyskinesia
作者: An, Hui-Mei1; Tan, Yun-Long1; Shi, Jing1; Wang, Zhi-Ren1; Li, Jia1; Wang, Yue-Chan1; Kosten, Thomas R.3,4; Zhou, Dong Feng2; Yang, Fu-De1; Zhang, Xiang-Yang1,3,4
关键词: animal model ; antioxidant ; extract of Ginkgo biloba ; free radical ; rat ; tardive dyskinesia ; vacuous chewing movements ; vitamin E
刊名: BEHAVIOURAL PHARMACOLOGY
发表日期: 2013-10-01
DOI: 10.1097/FBP.0b013e3283656d87
卷: 24, 期:7, 页:610-616
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: INDUCED OROFACIAL DYSKINESIA ; PLACEBO-CONTROLLED TRIAL ; LONG-TERM TREATMENT ; DOUBLE-BLIND ; JAW MOVEMENTS ; POSSIBLE INVOLVEMENT ; ANIMAL-MODELS ; SUPEROXIDE-DISMUTASE ; PARKINSONIAN TREMOR ; OXIDATIVE STRESS
英文摘要:

Free radical-mediated abnormalities may contribute toward the pathogenesis of tardive dyskinesia (TD). Many studies have reported the protective antioxidant and free radical-scavenging activities of extract of Ginkgo biloba (EGb761) against free radical-induced cell damage and dysfunction. This study aimed to compare the efficacy of EGb761 with that of vitamin E for the prevention and treatment of TD in a rat model. We carried out two studies. First, rats were injected with haloperidol (2 mg/kg intraperitoneally) daily for 5 weeks. EGb761 (50mg/kg/day) or vitamin E (20mg/kg/day) were then administered for another 5 weeks, and their effects on vacuous chewing movements (VCMs) were compared. Second, we compared 10 weeks of haloperidol alone with 10 weeks of haloperidol plus EGb761 or vitamin E. The administration of haloperidol led to a progressive increase in VCMs, which peaked at week 5. In study one, EGb761 and vitamin E, administered by an oral gavage for 5 weeks during withdrawal from chronic haloperidol treatment, decreased VCMs significantly, showing 83.8 and 91.0% reduction, respectively, compared with the haloperidol-alone group. In study two, the concomitant administration of EGb761 and vitamin E led to significantly fewer VCMs, by 64.4 and 73.9%, respectively, compared with the haloperidol-alone group. There was no significant difference in either study between EGb761 and vitamin E treatment. EGb761 shows promise for the prevention and treatment of TD in a rat model with a magnitude that was similar to that of vitamin E. (C) 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.

语种: 英语
所属项目编号: 30770782 ; 81071086 ; 03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
项目资助者: National Natural Science Foundation of China ; Stanley Medical Research Institute ; United States National Institute of Health
WOS记录号: WOS:000326971200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57751
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Michael E DeBakey VA Med Ctr, Houston, TX USA
3.Peking Univ, Beijing Huilongguan Hosp, Psychiat Res Ctr, Beijing 100871, Peoples R China
4.Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
An, Hui-Mei,Tan, Yun-Long,Shi, Jing,et al. Extract of Ginkgo biloba is equivalent to vitamin E in attenuating and preventing vacuous chewing movements in a rat model of tardive dyskinesia[J]. BEHAVIOURAL PHARMACOLOGY,2013,24(7):610-616.
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