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学科主题: 临床医学
题名:
Characterisation of the IgE-binding immunodominant epitopes on Ara h1
作者: Cong, YanJun1,2; Lou, Fei1; Xue, WenTong1; Li, LinFeng3; Chen, MingHai1
关键词: peanut allergy ; Ara h1 ; IgE-binding epitope
刊名: FOOD AND AGRICULTURAL IMMUNOLOGY
发表日期: 2008
DOI: 10.1080/09540100802172599
卷: 19, 期:3, 页:175-185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
研究领域[WOS]: Chemistry ; Food Science & Technology ; Immunology ; Toxicology
关键词[WOS]: MAJOR PEANUT ALLERGEN ; MUTATIONAL ANALYSIS ; FOOD ALLERGENS ; IDENTIFICATION ; PROTEINS ; HYPERSENSITIVITY ; ARA-H-1
英文摘要:

Peanut allergy is one of the most severe food allergies due to its persistency and life-threatening character. Serum IgE from patients with documented peanut hypersensitivity reactions and synthetic peptides were used to screen the linear IgE-binding epitopes on the major peanut allergen, Ara h 1. Five major epitopes that bound peanut-specific serum IgE from more than 60% of patients tested were identified. Mutational analysis of the immunodominant epitope showed that single amino acid changes had dramatic effects on IgE-binding characteristics. Mapping and characterisation of the IgE-binding epitopes on Ara h1 could be used in future immunotherapeutic approaches for peanut allergy disease.

语种: 英语
WOS记录号: WOS:000258500300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57754
Appears in Collections:北京大学第三临床医学院_皮肤科_期刊论文

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作者单位: 1.China Agr Univ, Dept Food Sci & Nutr Engn, Beijing 100094, Peoples R China
2.Inner Mongolia Yili Ind Grp Co Ltd, Ctr Technol, Hohhot, Peoples R China
3.Peking Univ, Dept Dermatol, Third Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Cong, YanJun,Lou, Fei,Xue, WenTong,et al. Characterisation of the IgE-binding immunodominant epitopes on Ara h1[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2008,19(3):175-185.
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