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学科主题临床医学
Characterisation of the IgE-binding immunodominant epitopes on Ara h1
Cong, YanJun1,2; Lou, Fei1; Xue, WenTong1; Li, LinFeng3; Chen, MingHai1
关键词Peanut Allergy Ara H1 Ige-binding Epitope
刊名FOOD AND AGRICULTURAL IMMUNOLOGY
2008
DOI10.1080/09540100802172599
19期:3页:175-185
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Immunology ; Toxicology
研究领域[WOS]Chemistry ; Food Science & Technology ; Immunology ; Toxicology
关键词[WOS]MAJOR PEANUT ALLERGEN ; MUTATIONAL ANALYSIS ; FOOD ALLERGENS ; IDENTIFICATION ; PROTEINS ; HYPERSENSITIVITY ; ARA-H-1
英文摘要

Peanut allergy is one of the most severe food allergies due to its persistency and life-threatening character. Serum IgE from patients with documented peanut hypersensitivity reactions and synthetic peptides were used to screen the linear IgE-binding epitopes on the major peanut allergen, Ara h 1. Five major epitopes that bound peanut-specific serum IgE from more than 60% of patients tested were identified. Mutational analysis of the immunodominant epitope showed that single amino acid changes had dramatic effects on IgE-binding characteristics. Mapping and characterisation of the IgE-binding epitopes on Ara h1 could be used in future immunotherapeutic approaches for peanut allergy disease.

语种英语
WOS记录号WOS:000258500300001
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57754
Collection北京大学第三临床医学院_皮肤科
作者单位1.China Agr Univ, Dept Food Sci & Nutr Engn, Beijing 100094, Peoples R China
2.Inner Mongolia Yili Ind Grp Co Ltd, Ctr Technol, Hohhot, Peoples R China
3.Peking Univ, Dept Dermatol, Third Hosp, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Cong, YanJun,Lou, Fei,Xue, WenTong,et al. Characterisation of the IgE-binding immunodominant epitopes on Ara h1[J]. FOOD AND AGRICULTURAL IMMUNOLOGY,2008,19(3):175-185.
APA Cong, YanJun,Lou, Fei,Xue, WenTong,Li, LinFeng,&Chen, MingHai.(2008).Characterisation of the IgE-binding immunodominant epitopes on Ara h1.FOOD AND AGRICULTURAL IMMUNOLOGY,19(3),175-185.
MLA Cong, YanJun,et al."Characterisation of the IgE-binding immunodominant epitopes on Ara h1".FOOD AND AGRICULTURAL IMMUNOLOGY 19.3(2008):175-185.
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