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Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy
Su, Yu-Wen1; Liang, Chen1; Jin, Hong-Fang1; Tang, Xiu-Ying2; Han, Wei1; Chai, Li-Jun2; Zhang, Chun-Yu1; Geng, Bin3,4; Tang, Chao-Shu3,4; Du, Jun-Bao1,4
关键词Adriamycin Dilated Cardiomyopathy Hydrogen Sulfide Oxidative Stress
刊名CIRCULATION JOURNAL
2009-04-01
73期:4页:741-749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]OXIDATIVE STRESS ; RADICAL FORMATION ; H2S ; DYSFUNCTION ; MITOCHONDRIA ; INHIBITOR ; SCAVENGER ; CELLS ; HEART ; RATS
英文摘要

Background: The present study was designed to investigate if hydrogen sulfide (H(2)S), a novel gasotransmitter, might have a regulatory effect on cardiac function and structure, as well as oxidative stress, in adriamycin (ADR)-induced cardiomyopathy.

Methods and Results: Hemodynamic measurements, histopathological examination and stereological ultrastructural analysis of mitochondria in ADR-treated rats showed characteristics of cardiomyopathy with remarkable greater size and smaller number of cardiomyocytic mitochondria and a significantly low H(2)S content in plasma and myocardium, but increased levels of thiobarbituric acid reactive substance (TBARs) and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in plasma and myocardium compared with controls (P < 0.01). However, administration of the H(2)S donor, NaHS, markedly improved cardiac function, as demonstrated by elevated left ventricular developed pressure (+/-LVdp/dtmax; P < 0.01) with ameliorated morphological alterations in the myocardium. Myocardial TBARs content decreased, whereas the activities of SOD and GSH-Px increased (P < 0.01 and P < 0.05, respectively).

Conclusions: Downregulation of endogenously-generated H(2)S is probably involved in the pathogenesis of ADR-induced cardiomyopathy, whereby H(2)S reduces lipid peroxidation, increases antioxidation, and inhibits oxidative stress injury. (Circ J 2009; 73: 741-749)

语种英语
WOS记录号WOS:000264733000027
项目编号30425010 ; 2006CB503807 ; 30630031 ; 30821001 ; 30801251
资助机构National Natural Science Foundation for Distinguished Young Scholars ; People&prime ; s Republic of China ; National Natural Science Foundation of China
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57758
专题北京大学第一临床医学院_电镜室
北京大学基础医学院
北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Med, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Su, Yu-Wen,Liang, Chen,Jin, Hong-Fang,et al. Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy[J]. CIRCULATION JOURNAL,2009,73(4):741-749.
APA Su, Yu-Wen.,Liang, Chen.,Jin, Hong-Fang.,Tang, Xiu-Ying.,Han, Wei.,...&Du, Jun-Bao.(2009).Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy.CIRCULATION JOURNAL,73(4),741-749.
MLA Su, Yu-Wen,et al."Hydrogen Sulfide Regulates Cardiac Function and Structure in Adriamycin-Induced Cardiomyopathy".CIRCULATION JOURNAL 73.4(2009):741-749.
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