IR@PKUHSC  > 北京大学药学院
学科主题药学
Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes
Gu, Keli; Bi, Lanrong; Zhao, Ming; Wang, Chao; Ju, Jingfang; Peng, Shiqi
关键词Chemoprevention Chemo-enzymatic Synthesis Anti-inflammatory Activity 2 Structure-activity 5-disubstituted-dioxacycloalkanes Relationship Study
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2007-09-15
DOI10.1016/j.bmc.2007.06.018
15期:18页:6273-6290
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]PROSTAGLANDIN G/H SYNTHASE ; PENICILLIN-G ACYLASE ; KETOROLAC TROMETHAMINE ; COLORECTAL-CANCER ; DRUG TRANSPORT ; CACO-2 CELLS ; PERMEABILITY ; PREVENTION ; CHROMATOGRAPHY ; INFLAMMATION
英文摘要

A new series of optically pure 5-amino-2-substitutedphenyl-1,3-dioxacyclozilkanes were designed and synthesized via a chemo-enzymatic combined method to develop new chemoprevention agents. Twenty-four of newly synthesized compounds significantly inhibited xylene-induced rat ear edema and exhibited comparable or better anti-inflammatory activities than the reference drug aspirin. Treatment of these anti-inflammatory agents did not prolong the tail bleeding time in rat. In addition, 5-amino-2-substitutedphenyl- I 3-dioxacycloalkanes exhibited good membrane permeability based on in vitro Caco-2 cell monolayer permeability assay. Furthermore, some preliminary structure-activity relationships were further analyzed among these compounds. Taken together, 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes may represent a new class of anti-inflammatory drugs with safer pharmacological profile. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000249194900029
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57759
专题北京大学药学院
作者单位1.Univ S Alabama, Mitchell Canc Inst, Mobile, AL 36688 USA
2.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
3.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gu, Keli,Bi, Lanrong,Zhao, Ming,et al. Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(18):6273-6290.
APA Gu, Keli,Bi, Lanrong,Zhao, Ming,Wang, Chao,Ju, Jingfang,&Peng, Shiqi.(2007).Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes.BIOORGANIC & MEDICINAL CHEMISTRY,15(18),6273-6290.
MLA Gu, Keli,et al."Toward the development of chemoprevention agents. Part II: Chemo-enzymatic synthesis and anti-inflammatory activities of a new class of 5-amino-2-substitutedphenyl-1,3-dioxacycloalkanes".BIOORGANIC & MEDICINAL CHEMISTRY 15.18(2007):6273-6290.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Gu, Keli]的文章
[Bi, Lanrong]的文章
[Zhao, Ming]的文章
百度学术
百度学术中相似的文章
[Gu, Keli]的文章
[Bi, Lanrong]的文章
[Zhao, Ming]的文章
必应学术
必应学术中相似的文章
[Gu, Keli]的文章
[Bi, Lanrong]的文章
[Zhao, Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。