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学科主题: 基础医学
题名:
AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker
作者: Ma, Jun1; Luo, Di-Xian1,2; Huang, Chenfei1; Shen, Yi1; Bu, Yiwen1; Markwell, Stephen3; Gao, John4; Liu, Jianghua8; Zu, Xuyu8; Cao, Zhe5; Gao, Zachary1; Lu, Fengmin6,7; Liao, Duan-Fang5,9; Cao, Deliang1
关键词: aldo-keto reductase 1B10 ; breast cancer ; disease-related survival ; prognostic marker ; serum marker
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2012-09-15
DOI: 10.1002/ijc.27618
卷: 131, 期:6, 页:E862-E871
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: KETO REDUCTASE FAMILY ; HUMAN ALDOSE REDUCTASE ; FATTY-ACID SYNTHASE ; LUNG-CANCER ; EXPRESSION ; B10 ; MEMBER ; CELLS ; HER-2 ; IDENTIFICATION
英文摘要:

Aldo-keto reductase 1B10 (AKR1B10) is a secretory protein that is upregulated with tumorigenic transformation of human mammary epithelial cells. This study demonstrated that AKR1B10 was overexpressed in 20 (71.4%) of 28 ductal carcinomas in situ, 184 (83.6%) of 220 infiltrating carcinomas and 28 (87.5%) of 32 recurrent tumors. AKR1B10 expression in breast cancer was correlated positively with tumor size (p = 0.0012) and lymph node metastasis (p = 0.0123) but inversely with disease-related survival (p = 0.0120). Univariate (p = 0.0077) and multivariate (p = 0.0192) analyses both suggested that AKR1B10, alone or together with tumor size and node status, is a significant prognostic factor for breast cancer. Silencing of AKR1B10 in BT-20 human breast cancer cells inhibited cell growth in culture and tumorigenesis in female nude mice. Importantly, AKR1B10 in the serum of breast cancer patients was significantly increased to 15.18 +/- 9.08 ng/ml [n = 50; 95% confidence interval (CI), 12.6017.76], with a high level up to 58.4 ng/ml, compared to 3.34 +/- 2.27 ng/ml in healthy donors (n = 60; 95% CI, 2.783.90). In these patients, AKR1B10 levels in serum were correlated with its expression in tumors (r = 0.8066; p < 0.0001). Together our data suggests that AKR1B10 is overexpressed in breast cancer and may be a novel prognostic factor and serum marker for this deadly disease.

语种: 英语
所属项目编号: N43CO-2011-00124 ; BC083555 ; 81170807
项目资助者: PHS 2011-1 SBIR Topic 304 Competitive Range (USA) ; Department of Defense Breast Cancer Research Program ; National Natural Science Foundation of China
WOS记录号: WOS:000306735700002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57762
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.So Illinois Univ, Sch Med, Simmons Canc Inst, Dept Med Microbiol Immunol & Cell Biol, Springfield, IL 62794 USA
2.First Peoples Hosp Chenzhou, Inst Translat Med, Chenzhou 423000, Peoples R China
3.So Illinois Univ, Sch Med, Div Stat & Res Consulting, Springfield, IL 62794 USA
4.Mem Med Ctr, Dept Pathol, Springfield, IL 62702 USA
5.Univ S China, Inst Pharm & Pharmacol, Coll Pharm & Life Sci, Hengyang 421001, Peoples R China
6.Peking Univ, Dept Microbiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
7.Peking Univ, Ctr Infect Dis, Hlth Sci Ctr, Beijing 100083, Peoples R China
8.Univ S China, Affiliated Hosp 1, Hengyang 421001, Peoples R China
9.Hunan Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Diagnost, Changsha 420108, Hunan, Peoples R China

Recommended Citation:
Ma, Jun,Luo, Di-Xian,Huang, Chenfei,et al. AKR1B10 overexpression in breast cancer: Association with tumor size, lymph node metastasis and patient survival and its potential as a novel serum marker[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(6):E862-E871.
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