北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 普通外科  > 期刊论文
学科主题: 临床医学
题名:
Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy
作者: Liu, Y.1; Xu, Y.2; Liu, Y.3; Zhang, Y.2; Wang, D.3; Xiu, D.1; Xu, Z.1; Zhou, X.1; Wu, J.2; Ling, X.1
刊名: BRITISH JOURNAL OF SURGERY
发表日期: 2011-03-01
DOI: 10.1002/bjs.7330
卷: 98, 期:3, 页:380-384
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery
研究领域[WOS]: Surgery
关键词[WOS]: CANCER-CELLS ; PROSTATE-CANCER ; FTIR ; CLASSIFICATION ; EXPLORATIONS ; TISSUES
英文摘要:

Background: A previous study demonstrated that Fourier transform infrared (FTIR) spectroscopy can distinguish thyroid cancer from benign thyroid lesions. The aim of this study was to explore the use of FTIR for identifying metastatic lymph nodes of papillary thyroid cancer in vitro, and distinguishing between metastatic and non-metastatic tissue.

Methods: Some 184 freshly removed cervical lymph nodes were obtained from 22 patients with papillary thyroid cancer undergoing thyroid surgery with lymph node dissection. Samples were measured by FTIR spectroscopy before being processed for histopathological diagnosis. The FTIR spectrum of each sample identified 13 bands from 1000 to 4000 cm(-1). The peak position, intensity and full width at half maximum of each absorbent band were measured, and the relative intensity ratios were calculated. The FTIR spectra of metastatic lymph nodes were compared with those of non-metastatic nodes, and a linear discriminant analysis was performed based on these data.

Results: Histopathological examination confirmed 61 metastatic and 123 non-metastatic lymph nodes. The FTIR parameters of metastatic and non-metastatic lymph nodes differed owing to the content or configuration alterations of nucleic acids, proteins, lipids and carbohydrates. The sensitivity for FTIR in diagnosing metastatic lymph nodes was 80.3 per cent, the specificity was 91.9 per cent and the accuracy was 88.0 per cent.

Conclusion: FTIR spectroscopy is a novel technique for detection of metastatic lymph nodes and may prove useful in surgery for papillary thyroid cancer.

语种: 英语
所属项目编号: 2072020
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000287164400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57763
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China

Recommended Citation:
Liu, Y.,Xu, Y.,Liu, Y.,et al. Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy[J]. BRITISH JOURNAL OF SURGERY,2011,98(3):380-384.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Liu, Y.]'s Articles
[Xu, Y.]'s Articles
[Liu, Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Liu, Y.]‘s Articles
[Xu, Y.]‘s Articles
[Liu, Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace