IR@PKUHSC  > 北京大学第三临床医学院  > 普通外科
学科主题临床医学
Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy
Liu, Y.1; Xu, Y.2; Liu, Y.3; Zhang, Y.2; Wang, D.3; Xiu, D.1; Xu, Z.1; Zhou, X.1; Wu, J.2; Ling, X.1
刊名BRITISH JOURNAL OF SURGERY
2011-03-01
DOI10.1002/bjs.7330
98期:3页:380-384
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
研究领域[WOS]Surgery
关键词[WOS]CANCER-CELLS ; PROSTATE-CANCER ; FTIR ; CLASSIFICATION ; EXPLORATIONS ; TISSUES
英文摘要

Background: A previous study demonstrated that Fourier transform infrared (FTIR) spectroscopy can distinguish thyroid cancer from benign thyroid lesions. The aim of this study was to explore the use of FTIR for identifying metastatic lymph nodes of papillary thyroid cancer in vitro, and distinguishing between metastatic and non-metastatic tissue.

Methods: Some 184 freshly removed cervical lymph nodes were obtained from 22 patients with papillary thyroid cancer undergoing thyroid surgery with lymph node dissection. Samples were measured by FTIR spectroscopy before being processed for histopathological diagnosis. The FTIR spectrum of each sample identified 13 bands from 1000 to 4000 cm(-1). The peak position, intensity and full width at half maximum of each absorbent band were measured, and the relative intensity ratios were calculated. The FTIR spectra of metastatic lymph nodes were compared with those of non-metastatic nodes, and a linear discriminant analysis was performed based on these data.

Results: Histopathological examination confirmed 61 metastatic and 123 non-metastatic lymph nodes. The FTIR parameters of metastatic and non-metastatic lymph nodes differed owing to the content or configuration alterations of nucleic acids, proteins, lipids and carbohydrates. The sensitivity for FTIR in diagnosing metastatic lymph nodes was 80.3 per cent, the specificity was 91.9 per cent and the accuracy was 88.0 per cent.

Conclusion: FTIR spectroscopy is a novel technique for detection of metastatic lymph nodes and may prove useful in surgery for papillary thyroid cancer.

语种英语
WOS记录号WOS:000287164400011
项目编号2072020
资助机构Beijing Natural Science Foundation
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57763
专题北京大学第三临床医学院_普通外科
作者单位1.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
2.Peking Univ, Coll Chem & Mol Engn, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Liu, Y.,Xu, Y.,Liu, Y.,et al. Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy[J]. BRITISH JOURNAL OF SURGERY,2011,98(3):380-384.
APA Liu, Y..,Xu, Y..,Liu, Y..,Zhang, Y..,Wang, D..,...&Ling, X..(2011).Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy.BRITISH JOURNAL OF SURGERY,98(3),380-384.
MLA Liu, Y.,et al."Detection of cervical metastatic lymph nodes in papillary thyroid carcinoma by Fourier transform infrared spectroscopy".BRITISH JOURNAL OF SURGERY 98.3(2011):380-384.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Y.]的文章
[Xu, Y.]的文章
[Liu, Y.]的文章
百度学术
百度学术中相似的文章
[Liu, Y.]的文章
[Xu, Y.]的文章
[Liu, Y.]的文章
必应学术
必应学术中相似的文章
[Liu, Y.]的文章
[Xu, Y.]的文章
[Liu, Y.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。