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学科主题: 临床医学
题名:
A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia
作者: Lu Jie; Zhao Yang-yu; Qiao Jie; Zhang Hong-jun; Ge Lin; Wei Yuan
关键词: metabolic syndrome ; severe preeclampsia ; cardiovascular disease
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2011-03-05
DOI: 10.3760/cma.j.issn.0366-6999.2011.05.026
卷: 124, 期:5, 页:775-779
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: PREGNANCY COMPLICATIONS ; CARDIOVASCULAR-DISEASE ; DIABETES-MELLITUS ; HEART-DISEASE ; RISK ; METAANALYSIS ; HYPERTENSION ; COHORT
英文摘要:

Background Women with a history of preeclampsia have twice the risk of cardiovascular diseases, and there is a graded relationship between the severity of preeclampsia and the risk of cardiac disease. Moreover, metabolic scores are associated with developing preeclampsia. However, since there are no diagnostic criteria for metabolic syndrome during pregnancy and pregnant women undergo metabolic changes, it is difficult to elucidate the relationship between preeclampsia and metabolic syndrome. We carried out a cross-sectional study to investigate the relationship between metabolic syndrome and preeclampsia among women with a history of severe preeclampsia shortly after an indexed pregnancy.

Methods We recruited 62 women with a history of severe preeclampsia 1 to 3 years after an indexed pregnancy. Blood pressure and body compositional indices were recorded. Fasting blood samples were tested for glucose, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, triglycerides, and insulin. A questionnaire was used to collect demographic data including pre-pregnancy weight and family history of diseases associated with cardiovascular diseases. Criteria for metabolic syndrome were defined by the National Cholesterol Education Program, Adult Treatment Panel III 2001 (NCEP III) and International Diabetes Federation 2005 (IDF). Data were analyzed by the alpha(2) test and multivariate Logistic regression.

Results According to NCEP III and IDF standards, 17 (27%) and 24 (39%) women, respectively, were identified as having metabolic syndrome. Being overweight pre-pregnancy and currently overweight were risk factors, and currently overweight was an independent risk factor. A combination of blood pressure and waist circumference was predictive of metabolic syndrome with a sensitivity of 91.67% and specificity of 94.74%.

Conclusions An unfavorable metabolic constitution in women may lead to metabolic syndrome, preeclampsia, and long-term cardiovascular disease. In women with severe preeclampsia, therapeutic interventions should include weight-control shortly after pregnancy, especially among women who were previously overweight. Chin Med J 2011;124(5):775-779

语种: 英语
WOS记录号: WOS:000289040600026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57766
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Gynecol & Obstet, Beijing 100191, Peoples R China

Recommended Citation:
Lu Jie,Zhao Yang-yu,Qiao Jie,et al. A follow-up study of women with a history of severe preeclampsia: relationship between metabolic syndrome and preeclampsia[J]. CHINESE MEDICAL JOURNAL,2011,124(5):775-779.
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