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Cascade synthesis of spirooxindole delta-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates
Wang, Shucheng; Huang, Xuhu; Wen, Yanzhao; Ge, Zemei; Wang, Xin; Li, Runtao
关键词Spirooxindole Delta-lactone Xanthate Radical Cyclization
刊名TETRAHEDRON
2015-10-21
DOI10.1016/j.tet.2015.08.039
71期:42页:8117-8122
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Chemistry
关键词[WOS]DIVERSITY-ORIENTED SYNTHESIS ; BAYLIS-HILLMAN ADDUCTS ; STRUCTURE-BASED DESIGN ; STEREOSELECTIVE-SYNTHESIS ; ONE-POT ; SPIROCYCLIC OXINDOLES ; ENANTIOSELECTIVE SYNTHESIS ; MULTICOMPONENT REACTIONS ; NATURAL-PRODUCTS ; MDM2 INHIBITORS
英文摘要

A novel and highly efficient cascade synthesis of spirooxindole delta-lactone derivatives from N-aryl hydroxymethylacrylamides and xanthates in good yields is described. The reaction proceeds through a radical addition/cyclization and ester exchange, in which two new C-C bonds and one C-O bond were formed. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号81172915
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000361865100020
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57779
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Shucheng,Huang, Xuhu,Wen, Yanzhao,et al. Cascade synthesis of spirooxindole delta-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates[J]. TETRAHEDRON,2015,71(42):8117-8122.
APA Wang, Shucheng,Huang, Xuhu,Wen, Yanzhao,Ge, Zemei,Wang, Xin,&Li, Runtao.(2015).Cascade synthesis of spirooxindole delta-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates.TETRAHEDRON,71(42),8117-8122.
MLA Wang, Shucheng,et al."Cascade synthesis of spirooxindole delta-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates".TETRAHEDRON 71.42(2015):8117-8122.
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