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学科主题临床医学
Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes
Huang, Xiaoyan; Huang, Fang; Yang, Deye1; Dong, Fengquan; Shi, Xiangxiang; Wang, Hongyu3; Zhou, Xi; Wang, Suyun; Dai, Shengchuan2
关键词Mir-122 Differential Expression Ventricular Septum Defect Apoptosis Hand2
刊名JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
2012-11-01
DOI10.1111/j.1582-4934.2012.01577.x
16期:11页:2637-2646
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Medicine, Research & Experimental
研究领域[WOS]Cell Biology ; Research & Experimental Medicine
关键词[WOS]CONGENITAL HEART-DISEASE ; TRANSCRIPTION FACTOR ; CANCER-CELLS ; HAND2 ; GENE ; RNA ; SENSITIVITY ; DEFECTS ; MIRNAS ; DHAND
英文摘要

The microRNAs (miRNAs) can post-transcriptionally regulate gene expression and heart development. The Pax-8 gene knockout mice have apparent heart abnormalities. This study investigated the role of miRNAs in regulation of cardiac apoptosis and development in the knockout mice. MicroRNA microarrays demonstrated differential expression of microRNAs between Pax-8-/- and Pax-8+/- mice, confirmed by real-time PCR. The miR-122 was up-regulated by 1.92 folds in Pax-8-/- mice. There were ventricular septum defects in Pax-8-/- mice, and increased numbers of apoptotic cells in the left ventricular wall and interventricular septum in Pax-8-/- mice. In H9C2 myocytes, treatment with miR-122 mimics or miR-122 inhibitor affects the expression of CCK-8 and activity of Caspase-3. The miR-122 is up-regulated in the myocytes of Pax-8-/- mice and may participate in the apoptotic gene expression and pathogenesis of heart development defect.

语种英语
WOS记录号WOS:000310555200008
项目编号30571050 ; Y2110112
资助机构National Natural Science Foundation of China ; Zhejiang Province Natural Science Foundation
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57782
专题北京大学首钢医院_心血管内科
作者单位1.Wenzhou Med Coll, Inst Cardiovasc Biol & Gene, Affiliated Hosp 1, Div Cardiol, Wenzhou 325000, Peoples R China
2.Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Div Cardiol, Pittsburgh, PA USA
3.Peking Univ, Shougang Hosp, Dept Vasc Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Huang, Xiaoyan,Huang, Fang,Yang, Deye,et al. Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2012,16(11):2637-2646.
APA Huang, Xiaoyan.,Huang, Fang.,Yang, Deye.,Dong, Fengquan.,Shi, Xiangxiang.,...&Dai, Shengchuan.(2012).Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes.JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,16(11),2637-2646.
MLA Huang, Xiaoyan,et al."Expression of microRNA-122 contributes to apoptosis in H9C2 myocytes".JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 16.11(2012):2637-2646.
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