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学科主题临床医学
TGF-beta-activated Kinase-1: A Potential Prognostic Marker for Clear Cell Renal Cell Carcinoma
Wei, Can1,2,3; Lai, Yong-Qing1; Li, Xian-Xin1,3; Ye, Jiong-Xian1,2,3
关键词Clear Cell Renal Cell Carcinoma Tak1 Tumorigenesis Prognosis
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2013
DOI10.7314/APJCP.2013.14.1.315
14期:1页:315-320
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Technology Program of Guangdong Province ; Biobank of Complex Diseases in Shenzhen ; National Natural Science Foundation of China ; Technology Program of Guangdong Province ; Biobank of Complex Diseases in Shenzhen ; National Natural Science Foundation of China
研究领域[WOS]Oncology
关键词[WOS]IL-1 SIGNALING PATHWAY ; NF-KAPPA-B ; PARTIAL NEPHRECTOMY ; MOLECULAR MARKERS ; CANCER CELLS ; TAK1 ; MATRIX-METALLOPROTEINASE-9 ; EXPRESSION ; APOPTOSIS ; PROGRESSION
英文摘要

Background: TGF-beta-activated kinase-1 (TAK1) has been found to be over-expressed in a variety of solid malignancies and related to tumor growth. The aim of this study was to evaluate the expression level of TAK1 in clear cell renal cell carcinoma (ccRCC) and assess its value as a novel prognostic marker. Methods: TAK1 mRNA was assessed in 51 paired ccRCC tissues and adjacent normal tissues (ADTs) by real-time PCR. Tissue TAK1 protein was also assessed in 91 ADTs and 177 samples of ccRCC immunohistochemically for evaluation of relationships with clinical characteristics. Results: RT-PCR showed that TAK1 RNA level was significantly higher in ccRCC tissues than in the paired ADTs and immunohistochemistry confirmed higher expression of TAK1 protein in ccRCC samples compared with ADTs. TAK1 protein expression in 177 ccRCC samples was significantly correlated with T stage, N classification, metastasis, recurrence and Fuhrman grade, but not age and gender. Patients with low TAK1 levels had a better survival outcome. TAK1 expression and N stage were independent prognosis factors for the overall survival of ccRCC patients. Conclusions: Overexpression of TAK1 predicts a poor prognosis in patients with ccRCC, so that TAK1 may serve as a novel prognostic marker.

语种英语
所属项目编号2011B061300046 ; CXC201005260001A ; 81101922
资助者Technology Program of Guangdong Province ; Biobank of Complex Diseases in Shenzhen ; National Natural Science Foundation of China ; Technology Program of Guangdong Province ; Biobank of Complex Diseases in Shenzhen ; National Natural Science Foundation of China
WOS记录号WOS:000319980200055
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57783
专题北京大学深圳医院_泌尿外科
作者单位1.Peking Univ, Shenzhen Hosp, Dept Urol, Shenzhen, Peoples R China
2.Univ Hong Kong, Shenzhen Hosp, Dept Med, Shenzhen, Peoples R China
3.Anhui Med Univ, Clin Coll 1, Med Program 7 Year, Hefei, Peoples R China
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GB/T 7714
Wei, Can,Lai, Yong-Qing,Li, Xian-Xin,et al. TGF-beta-activated Kinase-1: A Potential Prognostic Marker for Clear Cell Renal Cell Carcinoma[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2013,14(1):315-320.
APA Wei, Can,Lai, Yong-Qing,Li, Xian-Xin,&Ye, Jiong-Xian.(2013).TGF-beta-activated Kinase-1: A Potential Prognostic Marker for Clear Cell Renal Cell Carcinoma.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,14(1),315-320.
MLA Wei, Can,et al."TGF-beta-activated Kinase-1: A Potential Prognostic Marker for Clear Cell Renal Cell Carcinoma".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 14.1(2013):315-320.
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