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Revision of agents of black-grain eumycetoma in the order Pleosporales
Ahmed, S. A.1,2,3; van de Sande, W. W. J.4; Stevens, D. A.5; Fahal, A.6; van Diepeningen, A. D.2; Menken, S. B. J.3; de Hoog, G. S.2,3,7,8,9,10,11
关键词Madurella Mycetoma Pleosporales Taxonomy Trematosphaeriaceae
WOS标题词Science & Technology

Eumycetoma is a chronic fungal infection characterised by large subcutaneous masses and the presence of sinuses discharging coloured grains. The causative agents of black-grain eumycetoma mostly belong to the orders Sordariales and Pleosporales. The aim of the present study was to clarify the phylogeny and taxonomy of pleosporalean agents, viz. Madurella grisea, Medicopsis romeroi (syn.: Pyrenochaeta romeroi), Nigrograna mackinnonii (syn. Pyrenochaeta mackinnonii), Leptosphaeria senegalensis, L. tompkinsii, and Pseudochaetosphaeronema larense. A phylogenetic analysis based on five loci was performed: the Internal Transcribed Spacer (ITS), large (LSU) and small (SSU) subunit ribosomal RNA, the second largest RNA polymerase subunit (RPB2), and translation elongation factor 1-alpha (TEF1) gene. In addition, the morphological and physiological characteristics were determined. Three species were well-resolved at the family and genus level. Madurella grisea, L. senegalensis, and L. tompkinsii were found to belong to the family Trematospheriaceae and are reclassified as Trematosphaeria grisea comb. nov., Falciformispora senegalensis comb. nov., and F. tompkinsii comb. nov. Medicopsis romeroi and Pseudochaetosphaeronema larense were phylogenetically distant and both names are accepted. The genus Nigrograna is reduced to synonymy of Biatriospora and therefore N. mackinnonii is reclassified as B. mackinnonii comb. nov. Mycetoma agents in Pleosporales were phylogenetically quite diverse despite their morphological similarity in the formation of pycnidia, except for the ascosporulating genus Falciformispora (formerly in Leptosphaeria). Most of the species diagnosed from human mycetoma were found to be related to waterborne or marine fungi, suggesting an association of the virulence factors with oligotrophism or halotolerance.

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作者单位1.Univ Khartoum, Fac Med Lab Sci, Khartoum, Sudan
2.CBS KNAW Fungal Biodivers Ctr, NL-3584 CT Utrecht, Netherlands
3.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, NL-1012 WX Amsterdam, Netherlands
4.Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
5.Calif Inst Med Res, San Jose, CA 95128 USA
6.Univ Khartoum, Mycetoma Res Ctr, Khartoum, Sudan
7.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China
9.King Abdulassiz Univ, Jeddah, Saudi Arabia
10.Second Mil Med Univ, Changzheng Hosp, Shanghai Inst Med Mycol, Shanghai, Peoples R China
11.Univ Fed Parana, Basic Pathol Dept, Curitiba, Parana, Brazil
Recommended Citation
GB/T 7714
Ahmed, S. A.,van de Sande, W. W. J.,Stevens, D. A.,et al. Revision of agents of black-grain eumycetoma in the order Pleosporales[J]. PERSOONIA,2014,33:141-154.
APA Ahmed, S. A..,van de Sande, W. W. J..,Stevens, D. A..,Fahal, A..,van Diepeningen, A. D..,...&de Hoog, G. S..(2014).Revision of agents of black-grain eumycetoma in the order Pleosporales.PERSOONIA,33,141-154.
MLA Ahmed, S. A.,et al."Revision of agents of black-grain eumycetoma in the order Pleosporales".PERSOONIA 33(2014):141-154.
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