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学科主题: 药物依赖
题名:
Effects of carbamazepine on morphine-induced behavioral sensitization in mice
作者: Li, JX; Zhao, WL; Liang, HH
关键词: carbamazepine ; behavioral sensitization ; morphine ; mouse
刊名: BRAIN RESEARCH
发表日期: 2004-09-03
DOI: 10.1016/j.brainres.2004.05.082
卷: 1019, 期:1-2, 页:77-83
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LOCOMOTOR-ACTIVITY ; DOPAMINE RELEASE ; RECEPTOR ANTAGONISTS ; RAT STRIATUM ; ADENOSINE ; EXPRESSION ; BRAIN ; STIMULATION ; CAFFEINE ; SLICES
英文摘要:

Effects of carbamazepine on behavioral sensitization to morphine in mice has been investigated. Mice treated daily for 7 days with morphine (10 mg/kg) induced behavioral sensitization. Carbamazepine (10, 20, 40 mg/kg, i.p.) itself dose-dependently inhibited the locomotor activity of mice, but did not affect the acute morphine induced hyperactivity. Chronic treatment with carbamazepine had no effect on the development of morphine behavioral sensitization. Co-administration of carbamazepine 30 min prior to morphine had no significant effect on the development of behavioral sensitization. After the behavioral sensitization has been established, carbamazepine (10, 20, 40mg/kg, i.p.) did not affect the expression of morphine sensitization. However, carbamazepine (10, 20, 40mg/kg, i.p.) dose-dependently potentiated the transfer of morphine sensitization. The data of the present study implies that carbamazepine may influence the maintenance process of behavioral sensitization, which results in the enhancement of the transfer of behavioral sensitization. In clinic, the present results suggest that chronic use of carbamazepine might have abuse potential in opioid abusers. (C) 2004 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000223710800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57787
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Li, JX,Zhao, WL,Liang, HH. Effects of carbamazepine on morphine-induced behavioral sensitization in mice[J]. BRAIN RESEARCH,2004,1019(1-2):77-83.
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