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Effects of carbamazepine on morphine-induced behavioral sensitization in mice
Li, JX; Zhao, WL; Liang, HH
关键词Carbamazepine Behavioral Sensitization Morphine Mouse
刊名BRAIN RESEARCH
2004-09-03
DOI10.1016/j.brainres.2004.05.082
1019期:1-2页:77-83
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LOCOMOTOR-ACTIVITY ; DOPAMINE RELEASE ; RECEPTOR ANTAGONISTS ; RAT STRIATUM ; ADENOSINE ; EXPRESSION ; BRAIN ; STIMULATION ; CAFFEINE ; SLICES
英文摘要

Effects of carbamazepine on behavioral sensitization to morphine in mice has been investigated. Mice treated daily for 7 days with morphine (10 mg/kg) induced behavioral sensitization. Carbamazepine (10, 20, 40 mg/kg, i.p.) itself dose-dependently inhibited the locomotor activity of mice, but did not affect the acute morphine induced hyperactivity. Chronic treatment with carbamazepine had no effect on the development of morphine behavioral sensitization. Co-administration of carbamazepine 30 min prior to morphine had no significant effect on the development of behavioral sensitization. After the behavioral sensitization has been established, carbamazepine (10, 20, 40mg/kg, i.p.) did not affect the expression of morphine sensitization. However, carbamazepine (10, 20, 40mg/kg, i.p.) dose-dependently potentiated the transfer of morphine sensitization. The data of the present study implies that carbamazepine may influence the maintenance process of behavioral sensitization, which results in the enhancement of the transfer of behavioral sensitization. In clinic, the present results suggest that chronic use of carbamazepine might have abuse potential in opioid abusers. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000223710800010
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57787
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Li, JX,Zhao, WL,Liang, HH. Effects of carbamazepine on morphine-induced behavioral sensitization in mice[J]. BRAIN RESEARCH,2004,1019(1-2):77-83.
APA Li, JX,Zhao, WL,&Liang, HH.(2004).Effects of carbamazepine on morphine-induced behavioral sensitization in mice.BRAIN RESEARCH,1019(1-2),77-83.
MLA Li, JX,et al."Effects of carbamazepine on morphine-induced behavioral sensitization in mice".BRAIN RESEARCH 1019.1-2(2004):77-83.
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