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Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China
Lu, B.1; Wang, D.2,3,4; Zhou, H.2,3,4; Zhu, F.1; Li, D.1; Zhang, S.1; Shi, Y.1; Cui, Y.1; Huang, L.5; Wu, H.6
刊名EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2015-06-01
DOI10.1007/s10096-015-2342-9
34期:6页:1173-1179
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]MOLECULAR EPIDEMIOLOGY ; SURFACE-PROTEINS ; AGALACTIAE ; SEROTYPES ; VACCINE ; INFECTIONS ; DISEASE
英文摘要

Group B Streptococcus (GBS) is one of the major pathogens of severe newborn sepsis and meningitis. Understanding its regional molecular epidemiology is helpful for regulating efficient prevention practice. A total of 160 GBS strains were collected from colonized pregnant women in six hospital settings in Beijing, China. Polymerase chain reaction (PCR) assays were used to identify the pilus island (PI), alp genes profiling of the alpha-like protein family, and capsular polysaccharide (cps) serotyping. The clonal relationships between strains were investigated using multilocus sequence typing (MLST). All isolates carried at least one pilus island. The most frequently detected pilus island was PI-2a alone (70 isolates, 43.8 %). The most prevalent alp gene was rib (60 isolates, 37.5 %). Moreover, a strong association was noted between alp genes, serotyping, and pilus island profiles. The GBS isolates under study hinted similar molecular epidemical characteristics in Beijing to those reported worldwide, but having their regional distributional features.

语种英语
WOS记录号WOS:000354195100015
项目编号Z141107002514036
资助机构Beijing Municipal Science &amp ; Technology Commission (BMSTC), People&prime ; s Republic of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57790
专题北京大学第一临床医学院
北京大学第二临床医学院_药剂科
作者单位1.Civil Aviat Gen Hosp, Dept Lab Med, Beijing 100123, Peoples R China
2.Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China
3.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
4.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China
5.Peking Univ, Hosp 1, Dept Lab Med, Beijing 100034, Peoples R China
6.BGI Tianjin, Tianjin 300308, Peoples R China
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GB/T 7714
Lu, B.,Wang, D.,Zhou, H.,et al. Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2015,34(6):1173-1179.
APA Lu, B..,Wang, D..,Zhou, H..,Zhu, F..,Li, D..,...&Wu, H..(2015).Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China.EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,34(6),1173-1179.
MLA Lu, B.,et al."Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China".EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 34.6(2015):1173-1179.
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