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学科主题: 临床医学
题名:
Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China
作者: Lu, B.1; Wang, D.2,3,4; Zhou, H.2,3,4; Zhu, F.1; Li, D.1; Zhang, S.1; Shi, Y.1; Cui, Y.1; Huang, L.5; Wu, H.6
刊名: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
发表日期: 2015-06-01
DOI: 10.1007/s10096-015-2342-9
卷: 34, 期:6, 页:1173-1179
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: MOLECULAR EPIDEMIOLOGY ; SURFACE-PROTEINS ; AGALACTIAE ; SEROTYPES ; VACCINE ; INFECTIONS ; DISEASE
英文摘要:

Group B Streptococcus (GBS) is one of the major pathogens of severe newborn sepsis and meningitis. Understanding its regional molecular epidemiology is helpful for regulating efficient prevention practice. A total of 160 GBS strains were collected from colonized pregnant women in six hospital settings in Beijing, China. Polymerase chain reaction (PCR) assays were used to identify the pilus island (PI), alp genes profiling of the alpha-like protein family, and capsular polysaccharide (cps) serotyping. The clonal relationships between strains were investigated using multilocus sequence typing (MLST). All isolates carried at least one pilus island. The most frequently detected pilus island was PI-2a alone (70 isolates, 43.8 %). The most prevalent alp gene was rib (60 isolates, 37.5 %). Moreover, a strong association was noted between alp genes, serotyping, and pilus island profiles. The GBS isolates under study hinted similar molecular epidemical characteristics in Beijing to those reported worldwide, but having their regional distributional features.

语种: 英语
所属项目编号: Z141107002514036
项目资助者: Beijing Municipal Science &amp ; Technology Commission (BMSTC), People&prime ; s Republic of China
WOS记录号: WOS:000354195100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57790
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Civil Aviat Gen Hosp, Dept Lab Med, Beijing 100123, Peoples R China
2.Natl Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China
3.Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China
4.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310003, Zhejiang, Peoples R China
5.Peking Univ, Hosp 1, Dept Lab Med, Beijing 100034, Peoples R China
6.BGI Tianjin, Tianjin 300308, Peoples R China

Recommended Citation:
Lu, B.,Wang, D.,Zhou, H.,et al. Distribution of pilus islands and alpha-like protein genes of group B Streptococcus colonized in pregnant women in Beijing, China[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES,2015,34(6):1173-1179.
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