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学科主题: 临床医学
题名:
The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation
作者: Huo, Ming-Rui; Xu, Lan-Ping; Li, D.; Liu, Dai-Hong; Liu, Kai-Yan; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Y.; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词: haploidentical ; human leukocyte antigen disparity ; human leukocyte antigen-mismatched ; HSCT
刊名: CLINICAL TRANSPLANTATION
发表日期: 2012-03-01
DOI: 10.1111/j.1399-0012.2011.01499.x
卷: 26, 期:2, 页:284-291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Surgery ; Transplantation
研究领域[WOS]: Surgery ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; STEM-CELL TRANSPLANTATION ; UNRELATED DONOR ; CHRONIC GRAFT ; CLASS-I ; ACUTE-LEUKEMIA ; MISMATCHED/HAPLOIDENTICAL BLOOD ; HEMATOLOGICAL MALIGNANCIES ; IDENTICAL SIBLINGS ; HUMAN RECIPIENTS
英文摘要:

The relative importance of various human leukocyte antigen (HLA) loci has not been established for unmanipulated HLA-mismatched/haploidentical transplantation. To address this question, we analyzed the impact of HLA-A, HLA-B, HLA-DRB1, HLA-DRB3, HLA-DRB4, and HLA-DRB5 on the outcome of HLA-haploidentical transplantation. Four hundred and eighty-one donor-recipient pairs were fully typed before transplantation. In univariate analysis, HLA-B mismatch not only demonstrated significant adverse effects on acute graft-versus-host disease (GVHD) and transplant-related mortality but also was associated with reduced overall survival and leukemia-free survival (LFS). In multivariate analysis, HLA-B mismatch remained the independent risk factor for acute GVHD and transplant-related mortality. The high risk of disease and the female donor were found to be significant factors for reduced overall survival and LFS. Furthermore, multiple mismatch of the HLA locus was found to have no synergistic adverse effect on outcomes. Our results suggest that prospective matching of patients and donors for HLA-B antigen in the unshared HLA haplotype is warranted for HLA-mismatched/haploidentical transplantation.

语种: 英语
所属项目编号: 30725038 ; 2005-2010 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
WOS记录号: WOS:000302860400028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57792
Appears in Collections:北京大学第二临床医学院_北京大学血液病研究所_期刊论文

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作者单位: Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huo, Ming-Rui,Xu, Lan-Ping,Li, D.,et al. The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation[J]. CLINICAL TRANSPLANTATION,2012,26(2):284-291.
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