学科主题临床医学
The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation
Huo, Ming-Rui; Xu, Lan-Ping; Li, D.; Liu, Dai-Hong; Liu, Kai-Yan; Chen, Huan; Han, Wei; Chen, Yu-Hong; Wang, Y.; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词Haploidentical Human Leukocyte Antigen Disparity Human Leukocyte Antigen-mismatched Hsct
刊名CLINICAL TRANSPLANTATION
2012-03-01
DOI10.1111/j.1399-0012.2011.01499.x
26期:2页:284-291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery ; Transplantation
研究领域[WOS]Surgery ; Transplantation
关键词[WOS]VERSUS-HOST-DISEASE ; STEM-CELL TRANSPLANTATION ; UNRELATED DONOR ; CHRONIC GRAFT ; CLASS-I ; ACUTE-LEUKEMIA ; MISMATCHED/HAPLOIDENTICAL BLOOD ; HEMATOLOGICAL MALIGNANCIES ; IDENTICAL SIBLINGS ; HUMAN RECIPIENTS
英文摘要

The relative importance of various human leukocyte antigen (HLA) loci has not been established for unmanipulated HLA-mismatched/haploidentical transplantation. To address this question, we analyzed the impact of HLA-A, HLA-B, HLA-DRB1, HLA-DRB3, HLA-DRB4, and HLA-DRB5 on the outcome of HLA-haploidentical transplantation. Four hundred and eighty-one donor-recipient pairs were fully typed before transplantation. In univariate analysis, HLA-B mismatch not only demonstrated significant adverse effects on acute graft-versus-host disease (GVHD) and transplant-related mortality but also was associated with reduced overall survival and leukemia-free survival (LFS). In multivariate analysis, HLA-B mismatch remained the independent risk factor for acute GVHD and transplant-related mortality. The high risk of disease and the female donor were found to be significant factors for reduced overall survival and LFS. Furthermore, multiple mismatch of the HLA locus was found to have no synergistic adverse effect on outcomes. Our results suggest that prospective matching of patients and donors for HLA-B antigen in the unshared HLA haplotype is warranted for HLA-mismatched/haploidentical transplantation.

语种英语
WOS记录号WOS:000302860400028
项目编号30725038 ; 2005-2010 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57792
专题北京大学第二临床医学院_北京大学血液病研究所
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第二临床医学院_血液科
作者单位Peking Univ Peoples Hosp, Peking Univ Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Huo, Ming-Rui,Xu, Lan-Ping,Li, D.,et al. The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation[J]. CLINICAL TRANSPLANTATION,2012,26(2):284-291.
APA Huo, Ming-Rui.,Xu, Lan-Ping.,Li, D..,Liu, Dai-Hong.,Liu, Kai-Yan.,...&Huang, Xiao-Jun.(2012).The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation.CLINICAL TRANSPLANTATION,26(2),284-291.
MLA Huo, Ming-Rui,et al."The effect of HLA disparity on clinical outcome after HLA-haploidentical blood and marrow transplantation".CLINICAL TRANSPLANTATION 26.2(2012):284-291.
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