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学科主题: 临床医学
题名:
Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China
作者: He, Shengxi1,2,3; Yu, Longchuan3; Jia, Shaowei1,2; Chen, Qing1,2; Wang, Dongmei4; Hu, Shu1,2
关键词: long-term sustained naltrexone release ; opioid dependence ; projection of unilateral visual field ; event-related potential ; P100
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2011-01-25
DOI: 10.3969/j.issn.1673-5374.2011.03.013
卷: 6, 期:3, 页:236-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: HEROIN USERS ; ALCOHOLISM ; POTENTIALS ; RECOVERY ; ETHANOL ; P300
英文摘要:

Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential (ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.

语种: 英语
所属项目编号: 06027973 ; 2004B3600105 ; A2007592
项目资助者: Natural Science Foundation of Guangdong Province ; Science and Technology Development Program of Guangdong Province ; Medical Science Foundation Program of Guangdong Province
WOS记录号: WOS:000288061400013
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57800
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100112, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China

Recommended Citation:
He, Shengxi,Yu, Longchuan,Jia, Shaowei,et al. Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China[J]. NEURAL REGENERATION RESEARCH,2011,6(3):236-240.
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