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学科主题临床医学
Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China
He, Shengxi1,2,3; Yu, Longchuan3; Jia, Shaowei1,2; Chen, Qing1,2; Wang, Dongmei4; Hu, Shu1,2
关键词Long-term Sustained Naltrexone Release Opioid Dependence Projection Of Unilateral Visual Field Event-related Potential P100
刊名NEURAL REGENERATION RESEARCH
2011-01-25
DOI10.3969/j.issn.1673-5374.2011.03.013
6期:3页:236-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]HEROIN USERS ; ALCOHOLISM ; POTENTIALS ; RECOVERY ; ETHANOL ; P300
英文摘要

Very little is known about visual functional recovery following long-term naltrexone administration in opioid-dependent patients. In the present study, a portable event-related potential (ERP) working system was utilized to collect and record ERP in opioid-dependent patients and normal controls in visual half-field testing. In addition, the influence of long-term sustained naltrexone release on the visual nervous system was observed in opioid-dependent patients. Results revealed a significant main group effect in reaction time to visual signal stimulations. The reaction time of normal controls was shortest, but longest in opioid-dependent patients. The reaction time of long-term sustained naltrexone release group and compulsory detoxification group was similar to normal controls. A significant main group effect was also observed in P100 latency, and P100 latency in normal controls and the compulsory detoxification group was significantly decreased compared with the opioid-dependent patients. P100 amplitude at the Oz-electrode resulted in a significant main group effect. In particular, normal controls exhibited significant differences compared with long-term sustained release naltrexone and compulsory detoxification groups. These findings demonstrated that long-term sustained naltrexone release effectively ameliorated optic center function and improved visual sensitivity and reactions in opioid-dependent patients.

语种英语
WOS记录号WOS:000288061400013
项目编号06027973 ; 2004B3600105 ; A2007592
资助机构Natural Science Foundation of Guangdong Province ; Science and Technology Development Program of Guangdong Province ; Medical Science Foundation Program of Guangdong Province
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57800
专题北京大学深圳医院
北京大学第一临床医学院_医院管理办公室
作者单位1.Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Med Ctr, Shenzhen 518036, Guangdong, Peoples R China
2.Peking Univ, Shenzhen Hosp, Shenzhen 518036, Guangdong, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100112, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
He, Shengxi,Yu, Longchuan,Jia, Shaowei,et al. Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China[J]. NEURAL REGENERATION RESEARCH,2011,6(3):236-240.
APA He, Shengxi,Yu, Longchuan,Jia, Shaowei,Chen, Qing,Wang, Dongmei,&Hu, Shu.(2011).Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China.NEURAL REGENERATION RESEARCH,6(3),236-240.
MLA He, Shengxi,et al."Effects of long-term sustained naltrexone release on the optic center in opioid-dependent patients Case-control study in four provinces of China".NEURAL REGENERATION RESEARCH 6.3(2011):236-240.
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