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学科主题: 基础医学
题名:
Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary
作者: Sheng, Xia1; Weng, Jiaju2; Zhang, Haolin1; Li, Xiaonan1; Zhang, Mengyuan1; Xu, Meiyu1; Weng, Qiang1,3; Watanabe, Gen3,4; Taya, Kazuyoshi3,4
关键词: Folliculogenesis ; Immunohistochemistry ; Inhibin/activin subunits ; Ovary ; Wild ground squirrel
刊名: JOURNAL OF REPRODUCTION AND DEVELOPMENT
发表日期: 2012-10-01
卷: 58, 期:5, 页:531-536
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Agriculture, Dairy & Animal Science ; Reproductive Biology
研究领域[WOS]: Agriculture ; Reproductive Biology
关键词[WOS]: STIMULATING-HORMONE SECRETION ; HAMSTER MESOCRICETUS-AURATUS ; RAT ESTROUS-CYCLE ; CELLS IN-VITRO ; INHIBIN ALPHA ; SEASONAL-CHANGES ; CYTOCHROME-P450 AROMATASE ; MESSENGER-RNAS ; LUTEAL CELLS ; ACTIVIN
英文摘要:

The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and Western blotting have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (a, beta(A) and beta(B)). In the breeding season ovary, all three subunits were present in granulosa cells, theca cells of antral follicles and interstitial cells, with the strongest immunostaining in granulosa cells. Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. In the nonbreeding season ovary, inhibin/activin a and beta(A) subunits were weakly immunopositive in granulosa cells of early stage follicles, while beta(B) subunit was undetectable. The expression level of inhibin/activin subunit proteins were generally higher in the ovaries of the breeding season, and then decreased to a relatively low level during the nonbreeding season. The dynamic expression of inhibin/activin subunits indicated that they might play important paracrine and/or autocrine roles during the seasonal folliculogenesis of the wild ground squirrel.

语种: 英语
所属项目编号: IRT0607
项目资助者: Program for Changjiang Scholars and Innovative Research Teams in Universities from China
WOS记录号: WOS:000310716800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57803
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing 100083, Peoples R China
3.Tokyo Univ Agr & Technol, Cooperat Dept Vet Med, Vet Physiol Lab, Fac Agr, Tokyo 1838509, Japan
4.Gifu Univ, United Grad Sch Vet Sci, Dept Basic Sci, Gifu 5011193, Japan

Recommended Citation:
Sheng, Xia,Weng, Jiaju,Zhang, Haolin,et al. Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary[J]. JOURNAL OF REPRODUCTION AND DEVELOPMENT,2012,58(5):531-536.
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