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学科主题基础医学
Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary
Sheng, Xia1; Weng, Jiaju2; Zhang, Haolin1; Li, Xiaonan1; Zhang, Mengyuan1; Xu, Meiyu1; Weng, Qiang1,3; Watanabe, Gen3,4; Taya, Kazuyoshi3,4
关键词Folliculogenesis Immunohistochemistry Inhibin/activin Subunits Ovary Wild Ground Squirrel
刊名JOURNAL OF REPRODUCTION AND DEVELOPMENT
2012-10-01
58期:5页:531-536
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Agriculture, Dairy & Animal Science ; Reproductive Biology
研究领域[WOS]Agriculture ; Reproductive Biology
关键词[WOS]STIMULATING-HORMONE SECRETION ; HAMSTER MESOCRICETUS-AURATUS ; RAT ESTROUS-CYCLE ; CELLS IN-VITRO ; INHIBIN ALPHA ; SEASONAL-CHANGES ; CYTOCHROME-P450 AROMATASE ; MESSENGER-RNAS ; LUTEAL CELLS ; ACTIVIN
英文摘要

The intraovarian function of gonadally produced inhibin and activin has been extensively studied in experimental models for decades, yet their presence and function have been rarely reported in wild rodents. With our seasonal breeding model, the wild ground squirrel, we aimed to investigate the possible roles of these peptides in the seasonal folliculogenesis. Immunohistochemical staining and Western blotting have been used to detect the cellular localization and expression patterns of inhibin/activin subunits (a, beta(A) and beta(B)). In the breeding season ovary, all three subunits were present in granulosa cells, theca cells of antral follicles and interstitial cells, with the strongest immunostaining in granulosa cells. Following ovulation, the corpora lutea become a major site of inhibin/activin synthesis. In the nonbreeding season ovary, inhibin/activin a and beta(A) subunits were weakly immunopositive in granulosa cells of early stage follicles, while beta(B) subunit was undetectable. The expression level of inhibin/activin subunit proteins were generally higher in the ovaries of the breeding season, and then decreased to a relatively low level during the nonbreeding season. The dynamic expression of inhibin/activin subunits indicated that they might play important paracrine and/or autocrine roles during the seasonal folliculogenesis of the wild ground squirrel.

语种英语
WOS记录号WOS:000310716800005
项目编号IRT0607
资助机构Program for Changjiang Scholars and Innovative Research Teams in Universities from China
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57803
专题北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Beijing Forestry Univ, Coll Biol Sci & Technol, Beijing 100083, Peoples R China
3.Tokyo Univ Agr & Technol, Cooperat Dept Vet Med, Vet Physiol Lab, Fac Agr, Tokyo 1838509, Japan
4.Gifu Univ, United Grad Sch Vet Sci, Dept Basic Sci, Gifu 5011193, Japan
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GB/T 7714
Sheng, Xia,Weng, Jiaju,Zhang, Haolin,et al. Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary[J]. JOURNAL OF REPRODUCTION AND DEVELOPMENT,2012,58(5):531-536.
APA Sheng, Xia.,Weng, Jiaju.,Zhang, Haolin.,Li, Xiaonan.,Zhang, Mengyuan.,...&Taya, Kazuyoshi.(2012).Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary.JOURNAL OF REPRODUCTION AND DEVELOPMENT,58(5),531-536.
MLA Sheng, Xia,et al."Immunohistochemical Localization of Inhibin/Activin Subunits in the Wild Ground Squirrel (Citellus dauricus brandt) Ovary".JOURNAL OF REPRODUCTION AND DEVELOPMENT 58.5(2012):531-536.
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