|Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: A multicenter trial across China|
|Yang, Hai-Chen1,2; Xiang, Yu-Tao3,4; Liu, Tie-Bang1; Han, Rong1; Wang, Gang3; Hu, Chen3; Li, Ling-Jiang2; Wang, Xiao-Ping2; Peng, Hong-Jun2; Si, Tian-Mei5; Fang, Yi-Ru6; Yuan, Cheng-Mei6; Lu, Zheng7; Hu, Jian8; Chen, Zhi-Yu9; Huang, Yi10; Sun, Jing11; Li, Hui-Chun12; Zhang, Jin-Bei13; Angst, Jules14|
|关键词||Bipolar Disorder Major Depressive Disorder Screening Hypomania Hcl-32|
|刊名||JOURNAL OF AFFECTIVE DISORDERS|
|收录类别||SCI ; SSCI|
|WOS标题词||Science & Technology|
|类目[WOS]||Clinical Neurology ; Psychiatry|
|研究领域[WOS]||Neurosciences & Neurology ; Psychiatry|
|关键词[WOS]||BIPOLAR SPECTRUM DISORDER ; CHECKLIST HCL-32 ; QUESTIONNAIRE MDQ ; MOOD DISORDERS ; VALIDATION ; PREVALENCE ; DIAGNOSIS ; VALIDITY ; INSTRUMENT ; UNIPOLAR|
Aim: To investigate the results of the Hypomania Checklist-32 (HCL-32) administered as a screening instrument in clinical settings to mood disorders patients in the depressive phase.
Methods: A total of 1487 patients diagnosed and being treated for major depressive disorder (MDD) in 13 mental health centers across China were self-rated by the HCL-32 and independently examined by the Mini International Neuropsychiatric Interview (MINI).
Results: After examination by the MINI, 309 (20.8%) of the 1487 patients clinically diagnosed as having MDD satisfied DSM-IV criteria for bipolar disorder (BD): 118 (7.9%) for bipolar I disorder (BD-I) and 191 (12.8%) for bipolar II disorder (BD-II). The mean HCL-32 score of the BD patients was statistically higher than that of patients with unipolar depression (UD, major depressive disorder), BD-II higher than UD, while no significant difference between BD-I and BD-II. The HCL-32 distinguished between BD and UD (best cutoff score 14), between BD-II and UD (best cutoff 12). At the optimum cutoff of 12 between BD and UD, the sensitivity was 0.86, specificity 0.69.
Limitations: No standardized instruments were used to measure the severity of depressive symptoms. Depressed patients with a previous history of BD were excluded from this study.
Conclusions: The HCL-32 results in this multicenter study of patients in the depressive phase were similar to those of earlier, generally smaller-scale studies which subjects could be in any mood phases. A score of 12 could be used as the optimum cutoff between BD and UD to improve screening for BD-II if the HCL-32 was applied in clinical settings in China. (C) 2012 Elsevier B.V. All rights reserved.
|项目编号||2007BAI17B05 ; 200602032|
|资助机构||Ministry of Science and Technology of China ; scientific and technological bureau of Shenzhen in China ; AstraZeneca China|
|作者单位||1.Shenzhen Mental Hlth Ctr, Div Mood Disorders, Shenzhen, Guangdong, Peoples R China|
2.Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China
3.Capital Med Univ, Beijing Anding Hosp, Mood Disorders Ctr, Beijing, Peoples R China
4.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
5.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai 200030, Peoples R China
7.Tongji Univ, Sch Med, Shanghai Tongji Hosp, Shanghai 200092, Peoples R China
8.Harbin Med Univ, Hosp 1, Harbin, Heilongjiang Pr, Peoples R China
9.Hangzhou Seventh Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
10.Sichuan Univ, W China Hosp, Chengdu, Sichuan Provinc, Peoples R China
11.Nanjing Med Univ, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China
12.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
14.Univ Zurich, Hosp Psychiat, CH-8006 Zurich, Switzerland
|Yang, Hai-Chen,Xiang, Yu-Tao,Liu, Tie-Bang,et al. Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: A multicenter trial across China[J]. JOURNAL OF AFFECTIVE DISORDERS,2012,143(1-3):203-207.|
|APA||Yang, Hai-Chen.,Xiang, Yu-Tao.,Liu, Tie-Bang.,Han, Rong.,Wang, Gang.,...&Angst, Jules.(2012).Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: A multicenter trial across China.JOURNAL OF AFFECTIVE DISORDERS,143(1-3),203-207.|
|MLA||Yang, Hai-Chen,et al."Hypomanic symptoms assessed by the HCL-32 in patients with major depressive disorder: A multicenter trial across China".JOURNAL OF AFFECTIVE DISORDERS 143.1-3(2012):203-207.|