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Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts
Shi, Jie1; Jun, Wang1; Zhao, Li-Yan1; Xue, Yan-Xue1; Zhang, Xiang-Yang2; Kosten, Thomas R.2; Lu, Lin1
关键词Drug Cues Heroin Addiction Rapamycin Craving
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2009-08-01
DOI10.1016/j.ejphar.2009.05.011
615期:1-3页:108-112
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]LONG-TERM-MEMORY ; MACROMOLECULAR-SYNTHESIS ; SYNAPTIC PLASTICITY ; COCAINE ADDICTION ; NEURAL MECHANISMS ; INDUCED RESPONSES ; MAMMALIAN TARGET ; PATHWAY ; STRESS ; SIROLIMUS
英文摘要

The mammalian target of rapamycin is an evolutionarily conserved serine-threonine kinase (mTOR), which controls protein synthesis and catabolism in response to environmental cues. This randomized double-blind clinical trial enrolled 60 abstinent heroin addicts and randomly assigned them to three groups: placebo, 2.5 mg and 5 mg rapamycin. The participants were given the cue-reactivity paradigm with 5 min exposures to neutral and drug-related imagery while craving, anxiety, blood pressure and heart rate pre- and post-exposure were assessed. We found that drug-related cues increased both craving and anxiety of abstinent heroin addicts, and had no effect on blood pressure and heart rate. A single high-dose of rapamycin significantly reduced the craving, but not anxiety induced by drug-related cues. Our findings suggested that rapamycin merits outpatient clinical trials as a potential pharmacotherapy for relapse prevention from drug-related cue induced craving. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000268218100015
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57808
专题北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Shi, Jie,Jun, Wang,Zhao, Li-Yan,et al. Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2009,615(1-3):108-112.
APA Shi, Jie.,Jun, Wang.,Zhao, Li-Yan.,Xue, Yan-Xue.,Zhang, Xiang-Yang.,...&Lu, Lin.(2009).Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts.EUROPEAN JOURNAL OF PHARMACOLOGY,615(1-3),108-112.
MLA Shi, Jie,et al."Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts".EUROPEAN JOURNAL OF PHARMACOLOGY 615.1-3(2009):108-112.
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