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学科主题临床医学
Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation
Shi, Chunyan1,2; Lei, Yiming3; Han, Hongbin1,2; Zuo, Long1,2; Yan, Junhao2,4; He, Qingyuan1,2; Yuan, Lan5; Liu, Huipo6; Xu, Ge7; Xu, Weiguo8
刊名SCIENTIFIC REPORTS
2015-12-03
DOI10.1038/srep17673
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]STIMULUS-INDUCED CHANGES ; EXTRACELLULAR-SPACE ; RAT-BRAIN ; IN-VIVO ; DOPAMINE RELEASE ; WATER DIFFUSION ; DRUG-DELIVERY ; GROWTH-FACTOR ; TIME-SERIES ; MRI
英文摘要

The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation.

语种英语
WOS记录号WOS:000365701800002
项目编号81171080 ; 81471633 ; 91330103 ; 61450004 ; 61471005
资助机构National Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57812
专题北京大学第三临床医学院_放射科
北京大学医学信息学中心
作者单位1.Natl Nat Sci Fdn China, Beijing 100085, Peoples R China
2.Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
4.Beijing Key Lab Magnet Resonance Imaging Technol, Beijing 100191, Peoples R China
5.Peking Univ, Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China
6.Peking Univ, Sch Basic Med Sci, Dept Anat & Histol, Beijing 100191, Peoples R China
7.Peking Univ, Hlth Sci Ctr, Med & Hlth Anal Ctr, Beijing 100191, Peoples R China
8.Inst Appl Phys & Computat Math, Beijing 100094, Peoples R China
推荐引用方式
GB/T 7714
Shi, Chunyan,Lei, Yiming,Han, Hongbin,et al. Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation[J]. SCIENTIFIC REPORTS,2015,5.
APA Shi, Chunyan.,Lei, Yiming.,Han, Hongbin.,Zuo, Long.,Yan, Junhao.,...&Xu, Weiguo.(2015).Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation.SCIENTIFIC REPORTS,5.
MLA Shi, Chunyan,et al."Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation".SCIENTIFIC REPORTS 5(2015).
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