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学科主题: 药学
题名:
Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts
作者: Zhang, JC; Huang, J; Xu, SJ; Wang, K; Yu, SF; Zhang, TL; Yang, MS
关键词: lanthanum ; osteoclast ; osteoblast ; bone resorption ; cell-cell contact ; rare earths
刊名: JOURNAL OF RARE EARTHS
发表日期: 2005-08-01
卷: 23, 期:4, 页:496-501
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied
研究领域[WOS]: Chemistry
关键词[WOS]: RESORPTION IN-VITRO ; EXTRACELLULAR CALCIUM ; RARE-EARTH ; DIFFERENTIATION ; CELLS ; MODULATION ; CALCITONIN ; OSTEOPOROSIS
英文摘要:

The effects of lanthanum (III) on the bone resorbing activity of rabbit mature osteoclasts (OCs) in the presence of osteoblasts (OBs) were studied in vitro by measuring the number and area of absorption pits. La(III) at concentrations ranging from 1.00 x 10(-5) to 1.00 x 10(-8) mol (.) L-1 show no effect on mature OC number (P > 0.05). In the OC-OB co-culture systems without La(III), osteoblasts alone did not influence the pit number and area whether the two kinds of cells were in contact or not (P > 0.05). Under the OC-OB not-in-contact condition, the effect of La(III) on the bone-resorbing activity of OCs was similar to that of La(III) in the absence of OBs (P > 0.05). However, while OCs were in direct contact with OBs, the inhibitory effects of La(III) on OCs′ bone-resorbing activity decreased at the concentrations of 1.00 x 10(-5), 1.00 x 10(-6) and 1.00 x 10(-7) mol (.) L-1 and the promotion effects increased at 1.00 x 10(-8) mol (.) L-1 (P < 0.05). The results suggest that direct cell-cell contact between OC and OB be essential for OBs to play their role in regulating the response of OCs to La(III).

语种: 英语
WOS记录号: WOS:000232021000024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57819
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Clin, Beijing 100083, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Dept Chem, Baoding 071002, Peoples R China
3.Peking Univ, Stomato Hosp, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Capital Univ Med Sci, Sch Pharmaceut Sci, Beijing 100054, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Zhang, JC,Huang, J,Xu, SJ,et al. Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts[J]. JOURNAL OF RARE EARTHS,2005,23(4):496-501.
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