IR@PKUHSC  > 北京大学药学院
学科主题药学
Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts
Zhang, JC; Huang, J; Xu, SJ; Wang, K; Yu, SF; Zhang, TL; Yang, MS
关键词Lanthanum Osteoclast Osteoblast Bone Resorption Cell-cell Contact Rare Earths
刊名JOURNAL OF RARE EARTHS
2005-08-01
23期:4页:496-501
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied
研究领域[WOS]Chemistry
关键词[WOS]RESORPTION IN-VITRO ; EXTRACELLULAR CALCIUM ; RARE-EARTH ; DIFFERENTIATION ; CELLS ; MODULATION ; CALCITONIN ; OSTEOPOROSIS
英文摘要

The effects of lanthanum (III) on the bone resorbing activity of rabbit mature osteoclasts (OCs) in the presence of osteoblasts (OBs) were studied in vitro by measuring the number and area of absorption pits. La(III) at concentrations ranging from 1.00 x 10(-5) to 1.00 x 10(-8) mol (.) L-1 show no effect on mature OC number (P > 0.05). In the OC-OB co-culture systems without La(III), osteoblasts alone did not influence the pit number and area whether the two kinds of cells were in contact or not (P > 0.05). Under the OC-OB not-in-contact condition, the effect of La(III) on the bone-resorbing activity of OCs was similar to that of La(III) in the absence of OBs (P > 0.05). However, while OCs were in direct contact with OBs, the inhibitory effects of La(III) on OCs′ bone-resorbing activity decreased at the concentrations of 1.00 x 10(-5), 1.00 x 10(-6) and 1.00 x 10(-7) mol (.) L-1 and the promotion effects increased at 1.00 x 10(-8) mol (.) L-1 (P < 0.05). The results suggest that direct cell-cell contact between OC and OB be essential for OBs to play their role in regulating the response of OCs to La(III).

语种英语
WOS记录号WOS:000232021000024
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57819
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Clin, Beijing 100083, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Dept Chem, Baoding 071002, Peoples R China
3.Peking Univ, Stomato Hosp, Dept Oral Pathol, Beijing 100081, Peoples R China
4.Capital Univ Med Sci, Sch Pharmaceut Sci, Beijing 100054, Peoples R China
5.City Univ Hong Kong, Dept Biol & Chem, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, JC,Huang, J,Xu, SJ,et al. Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts[J]. JOURNAL OF RARE EARTHS,2005,23(4):496-501.
APA Zhang, JC.,Huang, J.,Xu, SJ.,Wang, K.,Yu, SF.,...&Yang, MS.(2005).Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts.JOURNAL OF RARE EARTHS,23(4),496-501.
MLA Zhang, JC,et al."Effects of lanthanum on bone resorbing activity of rabbit mature osteoclasts co-cultured with osteoblasts".JOURNAL OF RARE EARTHS 23.4(2005):496-501.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, JC]的文章
[Huang, J]的文章
[Xu, SJ]的文章
百度学术
百度学术中相似的文章
[Zhang, JC]的文章
[Huang, J]的文章
[Xu, SJ]的文章
必应学术
必应学术中相似的文章
[Zhang, JC]的文章
[Huang, J]的文章
[Xu, SJ]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。