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A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer
Shi, Ji-Feng; Sun, Meng-Ge; Li, Xiu-Ying; Zhao, Yao; Ju, Rui-Jun; Mu, Li-Min; Yan, Yan; Li, Xue-Tao; Zeng, Fan; Lu, Wan-Liang
关键词Targeted Sunitinib Liposomes Targeted Vinorelbine Liposomes Indicators For Vasculogenic Mimicry Channels Caspase Invasive Breast Cancer Anticancer Efficacy
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
2015-09-01
DOI10.1166/jbn.2015.2075
11期:9页:1568-1582
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Biomaterials
研究领域[WOS]Science & Technology - Other Topics ; Materials Science
关键词[WOS]CELL VASCULOGENIC MIMICRY ; RESISTANT LUNG-CANCER ; HEPATOCELLULAR-CARCINOMA ; TUMOR-GROWTH ; STEM-CELLS ; METASTASIS ; MECHANISM ; ANGIOGENESIS ; CONJUGATE ; APOPTOSIS
英文摘要

Regular chemotherapy cannot eradicate invasive breast cancer cells and the residual cancer cells will form vasculogenic mimicry (VM) channels under hypoxic conditions to provide nutrients for cancer masses prior to angiogenesis. This phenomenon is a major reason for the recurrence of invasive breast cancer after treatment. In this study, a novel type of targeted liposomes was developed by modifying a mitochondria-tropic material, D-a-tocopheryl polyethylene glycol 1000 succinate- triphenylphosphine conjugate (TPGS(1000)-TPP), to encapsulate sunitinib and vinorelbine separately and a combination of the two targeted drug liposomes was used to treat invasive breast cancer as well as VM channels. Evaluations were performed in breast cancer MCF-7 cells and highly invasive breast cancer MDA-MB-435S cells in Vitro and in mice. The results determined that the functional material (TPGS1000-TPP) and suitable size of the liposomes (90-100 nm) resulted in prolonged blood circulation, an enhanced permeability retention (EPR) effect in cancer tissue, and a mitochondrial targeting effect. Targeted drug liposonnes were internalized via cellular uptake and accumulated in the mitochondria of invasive breast cancer cells or VM channel-forming cancer cells to induce acute cytotoxic injury and apoptosis. Activated apoptotic enzymes caspase 9 and caspase 3 as well as down-regulated VM channel-forming indicators (MMP-9, EphA2, VE-Cadherin, FAK and HIF-1 alpha) contributed to significantly enhanced efficacy. Therefore, a combination of targeted sunitinib liposomes and targeted vinorelbine liposomes may provide an effective strategy for treating invasive breast cancer and prevent relapse arising from VM channels.

语种英语
WOS记录号WOS:000359391700005
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57820
专题北京大学药学院
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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Shi, Ji-Feng,Sun, Meng-Ge,Li, Xiu-Ying,et al. A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2015,11(9):1568-1582.
APA Shi, Ji-Feng.,Sun, Meng-Ge.,Li, Xiu-Ying.,Zhao, Yao.,Ju, Rui-Jun.,...&Lu, Wan-Liang.(2015).A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,11(9),1568-1582.
MLA Shi, Ji-Feng,et al."A Combination of Targeted Sunitinib Liposomes and Targeted Vinorelbine Liposomes for Treating Invasive Breast Cancer".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11.9(2015):1568-1582.
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