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学科主题: 临床医学
题名:
An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain
作者: Han HongBin1,2; Li Kai1,2; Yan JunHao3; Zhu Kai1,2; Fu Yu2,4
关键词: Gd-DTPA ; extracellular space ; quantitative imaging ; diffusion ; interstitial fluid
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2012-09-01
DOI: 10.1007/s11427-012-4361-4
卷: 55, 期:9, 页:782-787
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: CONVECTION-ENHANCED DELIVERY ; EXTRACELLULAR-SPACE ; MUTUAL-INFORMATION ; DIFFUSION ; REGISTRATION ; LYMPH
英文摘要:

The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38+-1.07)x10(-4) mm(2) s(-1) and (7.60 +/- 4.18)x10(-5) s(-1). Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium.

语种: 英语
所属项目编号: 30972811 ; 81171080 ; 81071148 ; 2012BAI15B009
项目资助者: National Natural Science Foundation of China ; Twelfth Five-year Plan for National Science and Technology of China
WOS记录号: WOS:000309236200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57823
Appears in Collections:北京大学第三临床医学院_放射科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
2.Beijing Key Lab Magnet Resonance Imaging Device &, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat Histol & Embryol, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Han HongBin,Li Kai,Yan JunHao,et al. An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain[J]. SCIENCE CHINA-LIFE SCIENCES,2012,55(9):782-787.
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