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学科主题: 基础医学
题名:
Development of Dendritic Cell System
作者: Wu, Li1,2; Dakic, Aleksandar1
关键词: dendritic cell ; development ; hemopoietic precursor ; plasmacytoid dendritic cell ; Flt3
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2004-04-01
卷: 1, 期:2, 页:112-118
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要:

The dendritic cell system contains conventional dendritic cells (DCs) and plasmacytoid pre-dendritic cells (pDCs). Both DCs and pDCs are bone marrow derived cells. Although the common functions of DCs are antigen- processing and T-lymphocyte activation, they differ in surface markers, migratory patterns, and cytokine output. These differences can determine the fate of the T cells they activate. Several subsets of mature DCs have been described in both mouse and human and the developmental processes of these specialized DC subsets have been studied extensively. The original concept that all DCs were of myeloid origin was questioned by several recent studies, which demonstrated that in addition to the DCs derived from myeloid precursors, some DCs could also be efficiently generated from lymphoid-restricted precursors. Moreover, it has been shown recently that both conventional DCs and pDCs can be generated by the Flt3 expressing hemopoietic pro-genitors regardless of their myeloid-or lymphoid-origin. These findings suggest an early developmental flexibility of precursors for DCs and pDCs. This review summarizes some recent observations on the development of DC system in both human and mouse.

语种: 英语
WOS记录号: WOS:000208922200005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57825
Appears in Collections:基础医学院_免疫学系_期刊论文

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DevelopmentofDendriticCellSystem_Aleksan.pdf(532KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing, Peoples R China

Recommended Citation:
Wu, Li,Dakic, Aleksandar. Development of Dendritic Cell System[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(2):112-118.
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