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学科主题临床医学
Meibomian Gland Dropout in Patients with Dry Eye Disease in China
Feng, Yun; Gao, Ziqing; Feng, Kang; Qu, Hongqiang; Hong, Jing
关键词Dry Eye Disease Meibomian Gland Non-contact Meibography System
刊名CURRENT EYE RESEARCH
2014-10-01
DOI10.3109/02713683.2014.891748
39期:10页:965-972
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]SHIHPAI EYE ; DYSFUNCTION ; PREVALENCE ; POPULATION ; ASSOCIATION ; SYMPTOMS ; TAIWAN ; AGE
英文摘要

Purpose: To examine the morphological changes in the meibomian glands of eyes of patients with dry eye disease using the non-contact infrared meibography system and to assess their relationship with meibomian dropout, signs, and tear-film function.

Methods: Subjects included 264 randomly selected patients (528 eyes) suffering from dry eye disease (95 males, 169 females; age range, 7-85 years; mean male age, 39.83 +/- 19.17 years; mean female age, 46.16 +/- 17.38 years). Tear-film break-up time (BUT) was measured and tear-film production was evaluated by the Schirmer test I (SIT). Subjective symptoms were also scored. The upper and lower eyelids were turned over, and the meibomian glands were observed using the non-contact meibography system. Partial or complete loss of the meibomian glands (meibomian dropout) was scored for each eyelid from grade 0 (no loss) through grade 3 (lost area was >2/3 of the total meibomian gland area).

Results: The average SIT result was 6.71 +/- 6.13 mm (range 0-30 mm) and that for BUT was 3.13 +/- 2.39 s (range 0-10 s). The average fluorescein staining score was 4.25 +/- 4.05 (range 0-12). In addition, the mean meibomian gland photographic score was 4.35 +/- 1.39. The correlation between the meibomian gland photographic scores and various ocular surface examinations were evaluated using Kendall′s correlation. SIT and BUT were significantly negatively correlated with the meibomian gland photographic score, whereas corneal fluorescein staining was positively correlated.

Conclusions: The results suggest a large proportion of meibomian dropout cases among patients with dry eye disease, indicating that treatment targeted at the meibomian gland will become an important direction for treating dry eye disease. Meibography is recommended as a routine test for dry eye disease.

语种英语
WOS记录号WOS:000342199700001
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57826
专题北京大学第三临床医学院_眼科
作者单位Peking Univ, Hosp 3, Ctr Eye, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100191, Peoples R China
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GB/T 7714
Feng, Yun,Gao, Ziqing,Feng, Kang,et al. Meibomian Gland Dropout in Patients with Dry Eye Disease in China[J]. CURRENT EYE RESEARCH,2014,39(10):965-972.
APA Feng, Yun,Gao, Ziqing,Feng, Kang,Qu, Hongqiang,&Hong, Jing.(2014).Meibomian Gland Dropout in Patients with Dry Eye Disease in China.CURRENT EYE RESEARCH,39(10),965-972.
MLA Feng, Yun,et al."Meibomian Gland Dropout in Patients with Dry Eye Disease in China".CURRENT EYE RESEARCH 39.10(2014):965-972.
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