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学科主题: 精神卫生
题名:
Adjunctive aripiprazole in the treatment of risperidone-induced hyperprolactinemia: A randomized, double-blind, placebo-controlled, dose-response study
作者: Chen, Jing-Xu1; Su, Yun-Ai2; Bian, Qing-Tao1; Wei, Li-He1; Zhang, Rong-Zhen1; Liu, Yan-Hong1; Correll, Christoph3; Soares, Jair C.4; Yang, Fu-De1; Wang, Shao-Li1; Zhang, Xiang-Yang1,4
关键词: Risperidone ; Aripiprazole ; Prolactin ; Hyperprolactinemia ; Intervention ; Placebo controlled trial ; Dose effect
刊名: PSYCHONEUROENDOCRINOLOGY
发表日期: 2015-08-01
DOI: 10.1016/j.psyneuen.2015.04.011
卷: 58, 页:130-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Neurosciences ; Psychiatry
研究领域[WOS]: Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry
关键词[WOS]: ANTIPSYCHOTIC-INDUCED HYPERPROLACTINEMIA ; PALIPERIDONE-INDUCED HYPERPROLACTINEMIA ; DOPAMINE PARTIAL AGONIST ; SCHIZOAFFECTIVE DISORDER ; SCHIZOPHRENIA-PATIENTS ; RECEPTOR OCCUPANCY ; PROLACTIN LEVELS ; CONTROLLED TRIAL ; POLYPHARMACY ; MULTICENTER
英文摘要:

Hyperprolactinemia is an unwanted adverse effect associated with several antipsychotics. The addition of partial dopamine receptor agonist aripiprazole may attenuate antipsychotic-induced hyperprolactinemia effectively. However, the ideal dosing regimen for this purpose is unknown. We aimed to evaluate the dose effects of adjunctive treatment with aripiprazole on prolactin levels and hyperprolactinemia in schizophrenia patients. Stable subjects 18-45 years old with schizophrenia and hyperprolactinemia (i.e., >24 ng/nnl for females and >20 ng/ml for males) were randomly assigned to receive 8 weeks of placebo (n=30) or oral aripiprazole 5 mg/day (n = 30), 10 mg/day (n = 29), or 20 mg/day (n = 30) added on to fixed dose risperidone treatment. Serum prolactin levels were measured at baseline and after 2, 4 and 8 weeks; clinical symptoms and side effects were assessed at baseline and week 8 using the Positive and Negative Syndrome Scale, Clinical Global Impressions Severity scale, Barnes Akathisia Scale, Simpson-Angus Scale and UKU Side Effects Rating Scale. Of 119 randomized patients, 107 (89.9%) completed the 8-week study. At study end, all three aripiprazole doses resulted in significantly lower prolactin levels (beginning at week 2), higher response rates (>= 30% prolactin reduction) and higher prolactin normalization rates than placebo. Effects were significantly greater in the 10 and 20 mg/day groups than the 5 rng/day group. No significant changes were observed in any treatment groups regarding psychopathology and adverse effect ratings. Adjunctive aripiprazole treatment was effective and safe for resolving risperidone-induced hyperprolactinemia, producing significant and almost maximal improvements by week 2 without significant effects on psychopathology and side effects. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009D003014000001
项目资助者: Funding for Beijing Outstanding Talent Training Projects, China
WOS记录号: WOS:000356738700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57833
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100871, Peoples R China
3.Zucker Hillside Hosp, Psychiat Res North ShoreLong Isl Jewish Hlth Syst, Glen Oaks, NY USA
4.Univ Texas Hlth Sci Ctr Houston, Harris Cty Psychiat Ctr, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Chen, Jing-Xu,Su, Yun-Ai,Bian, Qing-Tao,et al. Adjunctive aripiprazole in the treatment of risperidone-induced hyperprolactinemia: A randomized, double-blind, placebo-controlled, dose-response study[J]. PSYCHONEUROENDOCRINOLOGY,2015,58:130-140.
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