IR@PKUHSC  > 北京大学临床肿瘤学院  > 内镜中心
学科主题药学
The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model
Yang, Xiu-Wei; Huang, Xin; Ma, Lian; Wu, Qi; Xu, Wei
关键词Myristicaceae Myristica Fragrans Neolignans Intestinal Permeability Caco-2 Cell Monolayer
刊名PLANTA MEDICA
2010-10-01
DOI10.1055/s-0030-1249810
76期:14页:1587-1591
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]IN-VITRO ; DRUG TRANSPORT ; RAT PLASMA ; MACE ; ARIL ; CONSTITUENTS ; LIGNANS ; ABSORPTION ; NUTMEG ; HOUTT
英文摘要

The intestinal permeability and transport of 10 neolignans isolated from Myristica fragrans were studied by using the Caco-2 cell monolayer model. The 10 neolignans were measured by HPLC. Transport parameters and permeability coefficients were then calculated and compared with those of the model compounds, propranolol and atenolol. Among the 10 neolignans, the 8-O-4′-type neolignans demonstrated high permeability while the benzofuran-type neolignans were of poor to moderate permeability. Among them, eight neolignans were transported mainly via passive diffusion. These findings indicate that the 8-O-4′-type neolignans are well-absorbed compounds and can be used as oral leading compounds in drug discovery.

语种英语
WOS记录号WOS:000282366800017
项目编号Z0004105040311 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A01-02 ; 2006-BAI08B03-09 ; 2009ZX09301-010 ; 2009ZX09502-006
资助机构Beijing Science Foundation ; National High Technology Program ; National Sciences and Technology Program of China ; "Major New Medicine Project" in Mega-projects of Science Research of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57836
专题北京大学临床肿瘤学院_内镜中心
北京大学药学院_天然药物学系
北京大学口腔医学院_外科
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Xiu-Wei,Huang, Xin,Ma, Lian,et al. The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2010,76(14):1587-1591.
APA Yang, Xiu-Wei,Huang, Xin,Ma, Lian,Wu, Qi,&Xu, Wei.(2010).The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model.PLANTA MEDICA,76(14),1587-1591.
MLA Yang, Xiu-Wei,et al."The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model".PLANTA MEDICA 76.14(2010):1587-1591.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Xiu-Wei]的文章
[Huang, Xin]的文章
[Ma, Lian]的文章
百度学术
百度学术中相似的文章
[Yang, Xiu-Wei]的文章
[Huang, Xin]的文章
[Ma, Lian]的文章
必应学术
必应学术中相似的文章
[Yang, Xiu-Wei]的文章
[Huang, Xin]的文章
[Ma, Lian]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。