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学科主题: 药学
题名:
The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model
作者: Yang, Xiu-Wei; Huang, Xin; Ma, Lian; Wu, Qi; Xu, Wei
关键词: Myristicaceae ; Myristica fragrans ; neolignans ; intestinal permeability ; Caco-2 cell monolayer
刊名: PLANTA MEDICA
发表日期: 2010-10-01
DOI: 10.1055/s-0030-1249810
卷: 76, 期:14, 页:1587-1591
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: IN-VITRO ; DRUG TRANSPORT ; RAT PLASMA ; MACE ; ARIL ; CONSTITUENTS ; LIGNANS ; ABSORPTION ; NUTMEG ; HOUTT
英文摘要:

The intestinal permeability and transport of 10 neolignans isolated from Myristica fragrans were studied by using the Caco-2 cell monolayer model. The 10 neolignans were measured by HPLC. Transport parameters and permeability coefficients were then calculated and compared with those of the model compounds, propranolol and atenolol. Among the 10 neolignans, the 8-O-4′-type neolignans demonstrated high permeability while the benzofuran-type neolignans were of poor to moderate permeability. Among them, eight neolignans were transported mainly via passive diffusion. These findings indicate that the 8-O-4′-type neolignans are well-absorbed compounds and can be used as oral leading compounds in drug discovery.

语种: 英语
所属项目编号: Z0004105040311 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A01-02 ; 2006-BAI08B03-09 ; 2009ZX09301-010 ; 2009ZX09502-006
项目资助者: Beijing Science Foundation ; National High Technology Program ; National Sciences and Technology Program of China ; "Major New Medicine Project" in Mega-projects of Science Research of China
WOS记录号: WOS:000282366800017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57836
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Xiu-Wei,Huang, Xin,Ma, Lian,et al. The Intestinal Permeability of Neolignans from the Seeds of Myristica fragrans in the Caco-2 Cell Monolayer Model[J]. PLANTA MEDICA,2010,76(14):1587-1591.
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