IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Effect of amine functionalization of SBA-15 on controlled baicalin drug release
Wang, Hongsu1; Gao, Xiaohan1; Wang, Yanan1; Wang, Jianfeng1; Niu, Xiaodi1; Deng, Xuliang2
关键词Sol-gel Processes Sio2 Functional Applications Biomedical Applications
刊名CERAMICS INTERNATIONAL
2012-12-01
DOI10.1016/j.ceramint.2012.05.062
38期:8页:6931-6935
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Ceramics
资助者National High Technology Research and Development program (863 Program) ; Basic Research and Operational Costs of Jilin University, China ; China Postdoctoral Science Foundation ; National High Technology Research and Development program (863 Program) ; Basic Research and Operational Costs of Jilin University, China ; China Postdoctoral Science Foundation
研究领域[WOS]Materials Science
关键词[WOS]MESOPOROUS SILICA ; DELIVERY ; MCM-41 ; COPOLYMER ; TRIBLOCK ; SYSTEM ; PORES
英文摘要

In this paper, we present the release of baicalin from hexagonal periodic mesoporous silica SBA-15 and amino-functionalized mesoporous SBA-15 (A-SBA-15), which serve as drug delivery systems (SBA-15/baicalin and A-SBA-15/baicalin). The modified and drug loaded mesoporous materials were characterized by XRD, SEM, TEM, N-2 physisorption, IR, TG and HPLC. The results demonstrated that slightly higher amount of baicalin was loaded in APS-SBA-15, and the dissolution rate of baicalin from the A-SBA-15/baicalin was much faster than from the SBA-15/baicalin. A-SBA-15/baicalin as baicalin delivery system was better than SBA-15/baicalin because the faster dissolution rate compared with SBA-15/baicalin was more conducive to drug absorption. (C) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

语种英语
所属项目编号201 I AA030102 ; 3R211L416604 ; 421031196604 ; 450060445293 ; 801119606201
资助者National High Technology Research and Development program (863 Program) ; Basic Research and Operational Costs of Jilin University, China ; China Postdoctoral Science Foundation ; National High Technology Research and Development program (863 Program) ; Basic Research and Operational Costs of Jilin University, China ; China Postdoctoral Science Foundation
WOS记录号WOS:000309645000114
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57837
专题北京大学口腔医学院
作者单位1.Jilin Univ, Teaching Ctr Basic Courses, Changchun 130062, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, Hongsu,Gao, Xiaohan,Wang, Yanan,et al. Effect of amine functionalization of SBA-15 on controlled baicalin drug release[J]. CERAMICS INTERNATIONAL,2012,38(8):6931-6935.
APA Wang, Hongsu,Gao, Xiaohan,Wang, Yanan,Wang, Jianfeng,Niu, Xiaodi,&Deng, Xuliang.(2012).Effect of amine functionalization of SBA-15 on controlled baicalin drug release.CERAMICS INTERNATIONAL,38(8),6931-6935.
MLA Wang, Hongsu,et al."Effect of amine functionalization of SBA-15 on controlled baicalin drug release".CERAMICS INTERNATIONAL 38.8(2012):6931-6935.
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