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学科主题: 口腔医学
题名:
Effect of amine functionalization of SBA-15 on controlled baicalin drug release
作者: Wang, Hongsu1; Gao, Xiaohan1; Wang, Yanan1; Wang, Jianfeng1; Niu, Xiaodi1; Deng, Xuliang2
关键词: Sol-gel processes ; SiO2 ; Functional applications ; Biomedical applications
刊名: CERAMICS INTERNATIONAL
发表日期: 2012-12-01
DOI: 10.1016/j.ceramint.2012.05.062
卷: 38, 期:8, 页:6931-6935
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Ceramics
研究领域[WOS]: Materials Science
关键词[WOS]: MESOPOROUS SILICA ; DELIVERY ; MCM-41 ; COPOLYMER ; TRIBLOCK ; SYSTEM ; PORES
英文摘要:

In this paper, we present the release of baicalin from hexagonal periodic mesoporous silica SBA-15 and amino-functionalized mesoporous SBA-15 (A-SBA-15), which serve as drug delivery systems (SBA-15/baicalin and A-SBA-15/baicalin). The modified and drug loaded mesoporous materials were characterized by XRD, SEM, TEM, N-2 physisorption, IR, TG and HPLC. The results demonstrated that slightly higher amount of baicalin was loaded in APS-SBA-15, and the dissolution rate of baicalin from the A-SBA-15/baicalin was much faster than from the SBA-15/baicalin. A-SBA-15/baicalin as baicalin delivery system was better than SBA-15/baicalin because the faster dissolution rate compared with SBA-15/baicalin was more conducive to drug absorption. (C) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

语种: 英语
所属项目编号: 201 I AA030102 ; 3R211L416604 ; 421031196604 ; 450060445293 ; 801119606201
项目资助者: National High Technology Research and Development program (863 Program) ; Basic Research and Operational Costs of Jilin University, China ; China Postdoctoral Science Foundation
WOS记录号: WOS:000309645000114
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57837
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Jilin Univ, Teaching Ctr Basic Courses, Changchun 130062, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China

Recommended Citation:
Wang, Hongsu,Gao, Xiaohan,Wang, Yanan,et al. Effect of amine functionalization of SBA-15 on controlled baicalin drug release[J]. CERAMICS INTERNATIONAL,2012,38(8):6931-6935.
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