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学科主题: 临床医学
题名:
Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats
作者: Wang, W; Sun, C; Wang, X
关键词: orchidectomy ; calcitonin gene-related peptide ; acetylcholine ; norepinephrine
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2002-11-01
卷: 23, 期:11, 页:985-990
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: SMOOTH-MUSCLE CELLS ; ANDROGEN DEPRIVATION ; POSTMENOPAUSAL WOMEN ; INDUCED RELAXATION ; HORMONES AFFECT ; THORACIC AORTA ; NITRIC-OXIDE ; ESTROGEN ; ARTERY ; DEHYDROEPIANDROSTERONE
英文摘要:

AIM: To determine the long-term effects of orchidectomy on vasoreactivity. METHODS: Orchidectomized rats with or without hormone replacement were raised 1, 2, and 4 months. Vascular responses to norepinephrine, calcitonin gene-related peptide (CGRP), and acetylcholine were tested on three different arteries (thoracic aorta, pulmonary artery, and caudal artery) by functional experiments. RESULTS: Responses to norepinephrine, CGRP, and acetylcholine were not changed by 1 or 2 months deprivation of androgen. In aorta, the dose-response curve of CGRP was shifted to the left by 1 month of testosterone replacement. Response to norepinephrine was increased 4 months after orchidectomy and reversed by testosterone replacement in thoracic aorta. Orchidectomy did not affect CGRP- and acetylcholine-induced relaxation in all the arteries 4 months after orchidectomy. CONCLUSION: Compared to estrogen, the protective effects of androgen on vasoresponsiveness may be through inhibiting vasoconstriction, but is relatively weak.

语种: 英语
WOS记录号: WOS:000179049300005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57841
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Wang, W,Sun, C,Wang, X. Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats[J]. ACTA PHARMACOLOGICA SINICA,2002,23(11):985-990.
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