IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats
Wang, W; Sun, C; Wang, X
关键词Orchidectomy Calcitonin Gene-related Peptide Acetylcholine Norepinephrine
刊名ACTA PHARMACOLOGICA SINICA
2002-11-01
23期:11页:985-990
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]SMOOTH-MUSCLE CELLS ; ANDROGEN DEPRIVATION ; POSTMENOPAUSAL WOMEN ; INDUCED RELAXATION ; HORMONES AFFECT ; THORACIC AORTA ; NITRIC-OXIDE ; ESTROGEN ; ARTERY ; DEHYDROEPIANDROSTERONE
英文摘要

AIM: To determine the long-term effects of orchidectomy on vasoreactivity. METHODS: Orchidectomized rats with or without hormone replacement were raised 1, 2, and 4 months. Vascular responses to norepinephrine, calcitonin gene-related peptide (CGRP), and acetylcholine were tested on three different arteries (thoracic aorta, pulmonary artery, and caudal artery) by functional experiments. RESULTS: Responses to norepinephrine, CGRP, and acetylcholine were not changed by 1 or 2 months deprivation of androgen. In aorta, the dose-response curve of CGRP was shifted to the left by 1 month of testosterone replacement. Response to norepinephrine was increased 4 months after orchidectomy and reversed by testosterone replacement in thoracic aorta. Orchidectomy did not affect CGRP- and acetylcholine-induced relaxation in all the arteries 4 months after orchidectomy. CONCLUSION: Compared to estrogen, the protective effects of androgen on vasoresponsiveness may be through inhibiting vasoconstriction, but is relatively weak.

语种英语
WOS记录号WOS:000179049300005
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57841
专题北京大学第三临床医学院_心血管内科
作者单位Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China
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GB/T 7714
Wang, W,Sun, C,Wang, X. Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats[J]. ACTA PHARMACOLOGICA SINICA,2002,23(11):985-990.
APA Wang, W,Sun, C,&Wang, X.(2002).Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats.ACTA PHARMACOLOGICA SINICA,23(11),985-990.
MLA Wang, W,et al."Alteration of vascular response to norepinephrine, calcitonin gene-related peptide, and acetylcholine in orchidectomized rats".ACTA PHARMACOLOGICA SINICA 23.11(2002):985-990.
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