|Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre|
|Qu, Zhen1; Zheng, Xin1; Wang, Su-Xia2; Ao, Jie1; Zhou, Fu-De1; Chen, Min1; Liu, Gang1|
|关键词||Amyloidosis Biopsy Classification Clinical Pathology Diagnosis|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||PRIMARY SYSTEMIC AMYLOIDOSIS ; ABDOMINAL FAT PAD ; ASPIRATION ; DIAGNOSIS ; DISEASE ; KIDNEY ; BIOPSY|
Aim: To summarize the clinical and pathological features of renal amyloidosis in order to achieve early diagnosis.
Methods: The clinical and pathological data of 32 patients with renal amyloidosis, diagnosed by renal biopsy in one renal centre, were retrospectively analyzed. Immunohistochemistry of amyloid A protein and immunoglobulin light chains was further performed on the renal specimens for further classification.
Results: Twenty-four out of the 32 patients (75%) were not considered to have renal amyloidosis by local physicians; 91.7% (22/24) of them had at least one of the following signs: bodyweight loss, organ enlargement and decreased blood pressure. Twenty-nine out of the 32 patients (90.6%) were over 40 years, 30 patients (93.8%) had nephrotic syndrome, and 21 patients (65.6%) were found to have monoclonal light chain in serum or urine by immunofixation. Six patients (18.8%) were negative by Congo red stain and were diagnosed as having early renal amyloidosis by electron microscopy. Twenty-eight patients were diagnosed as having AL amyloidosis, two were suspected of having AL amyloidosis, one had AA amyloidosis and the status of the remaining patient was undetermined.
Conclusion: Renal amyloidosis is frequently neglected by local physicians in China. Middle-aged nephrotic patients with weight loss, organ enlargement and monoclonal light chains in serum or urine should be highly suspected of the disease. Renal biopsies, especially electron microscopy, play a crucial role in the early diagnosis of renal amyloidosis.
|资助机构||Peking University First Hospital|
|作者单位||1.Peking Univ, Dept Med, Div Renal, Minist Hlth China,Key Lab Renal Dis, Beijing 100871, Peoples R China|
2.Peking Univ, Electron Microscopy Div, Peking Univ Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100871, Peoples R China
|Qu, Zhen,Zheng, Xin,Wang, Su-Xia,et al. Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre[J]. NEPHROLOGY,2010,15(1):102-107.|
|APA||Qu, Zhen.,Zheng, Xin.,Wang, Su-Xia.,Ao, Jie.,Zhou, Fu-De.,...&Liu, Gang.(2010).Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre.NEPHROLOGY,15(1),102-107.|
|MLA||Qu, Zhen,et al."Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre".NEPHROLOGY 15.1(2010):102-107.|