IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre
Qu, Zhen1; Zheng, Xin1; Wang, Su-Xia2; Ao, Jie1; Zhou, Fu-De1; Chen, Min1; Liu, Gang1
关键词Amyloidosis Biopsy Classification Clinical Pathology Diagnosis
刊名NEPHROLOGY
2010-02-01
DOI10.1111/j.1440-1797.2009.01127.x
15期:1页:102-107
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]PRIMARY SYSTEMIC AMYLOIDOSIS ; ABDOMINAL FAT PAD ; ASPIRATION ; DIAGNOSIS ; DISEASE ; KIDNEY ; BIOPSY
英文摘要

Aim: To summarize the clinical and pathological features of renal amyloidosis in order to achieve early diagnosis.

Methods: The clinical and pathological data of 32 patients with renal amyloidosis, diagnosed by renal biopsy in one renal centre, were retrospectively analyzed. Immunohistochemistry of amyloid A protein and immunoglobulin light chains was further performed on the renal specimens for further classification.

Results: Twenty-four out of the 32 patients (75%) were not considered to have renal amyloidosis by local physicians; 91.7% (22/24) of them had at least one of the following signs: bodyweight loss, organ enlargement and decreased blood pressure. Twenty-nine out of the 32 patients (90.6%) were over 40 years, 30 patients (93.8%) had nephrotic syndrome, and 21 patients (65.6%) were found to have monoclonal light chain in serum or urine by immunofixation. Six patients (18.8%) were negative by Congo red stain and were diagnosed as having early renal amyloidosis by electron microscopy. Twenty-eight patients were diagnosed as having AL amyloidosis, two were suspected of having AL amyloidosis, one had AA amyloidosis and the status of the remaining patient was undetermined.

Conclusion: Renal amyloidosis is frequently neglected by local physicians in China. Middle-aged nephrotic patients with weight loss, organ enlargement and monoclonal light chains in serum or urine should be highly suspected of the disease. Renal biopsies, especially electron microscopy, play a crucial role in the early diagnosis of renal amyloidosis.

语种英语
WOS记录号WOS:000274453700016
资助机构Peking University First Hospital
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57847
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
作者单位1.Peking Univ, Dept Med, Div Renal, Minist Hlth China,Key Lab Renal Dis, Beijing 100871, Peoples R China
2.Peking Univ, Electron Microscopy Div, Peking Univ Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Qu, Zhen,Zheng, Xin,Wang, Su-Xia,et al. Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre[J]. NEPHROLOGY,2010,15(1):102-107.
APA Qu, Zhen.,Zheng, Xin.,Wang, Su-Xia.,Ao, Jie.,Zhou, Fu-De.,...&Liu, Gang.(2010).Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre.NEPHROLOGY,15(1),102-107.
MLA Qu, Zhen,et al."Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre".NEPHROLOGY 15.1(2010):102-107.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qu, Zhen]的文章
[Zheng, Xin]的文章
[Wang, Su-Xia]的文章
百度学术
百度学术中相似的文章
[Qu, Zhen]的文章
[Zheng, Xin]的文章
[Wang, Su-Xia]的文章
必应学术
必应学术中相似的文章
[Qu, Zhen]的文章
[Zheng, Xin]的文章
[Wang, Su-Xia]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。