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学科主题: 临床医学
题名:
Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre
作者: Qu, Zhen1; Zheng, Xin1; Wang, Su-Xia2; Ao, Jie1; Zhou, Fu-De1; Chen, Min1; Liu, Gang1
关键词: amyloidosis ; biopsy ; classification ; clinical pathology ; diagnosis
刊名: NEPHROLOGY
发表日期: 2010-02-01
DOI: 10.1111/j.1440-1797.2009.01127.x
卷: 15, 期:1, 页:102-107
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: PRIMARY SYSTEMIC AMYLOIDOSIS ; ABDOMINAL FAT PAD ; ASPIRATION ; DIAGNOSIS ; DISEASE ; KIDNEY ; BIOPSY
英文摘要:

Aim: To summarize the clinical and pathological features of renal amyloidosis in order to achieve early diagnosis.

Methods: The clinical and pathological data of 32 patients with renal amyloidosis, diagnosed by renal biopsy in one renal centre, were retrospectively analyzed. Immunohistochemistry of amyloid A protein and immunoglobulin light chains was further performed on the renal specimens for further classification.

Results: Twenty-four out of the 32 patients (75%) were not considered to have renal amyloidosis by local physicians; 91.7% (22/24) of them had at least one of the following signs: bodyweight loss, organ enlargement and decreased blood pressure. Twenty-nine out of the 32 patients (90.6%) were over 40 years, 30 patients (93.8%) had nephrotic syndrome, and 21 patients (65.6%) were found to have monoclonal light chain in serum or urine by immunofixation. Six patients (18.8%) were negative by Congo red stain and were diagnosed as having early renal amyloidosis by electron microscopy. Twenty-eight patients were diagnosed as having AL amyloidosis, two were suspected of having AL amyloidosis, one had AA amyloidosis and the status of the remaining patient was undetermined.

Conclusion: Renal amyloidosis is frequently neglected by local physicians in China. Middle-aged nephrotic patients with weight loss, organ enlargement and monoclonal light chains in serum or urine should be highly suspected of the disease. Renal biopsies, especially electron microscopy, play a crucial role in the early diagnosis of renal amyloidosis.

语种: 英语
项目资助者: Peking University First Hospital
WOS记录号: WOS:000274453700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57847
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Dept Med, Div Renal, Minist Hlth China,Key Lab Renal Dis, Beijing 100871, Peoples R China
2.Peking Univ, Electron Microscopy Div, Peking Univ Hosp 1, Inst Nephrol,Key Lab Renal Dis,Minist Hlth China, Beijing 100871, Peoples R China

Recommended Citation:
Qu, Zhen,Zheng, Xin,Wang, Su-Xia,et al. Clinical and pathological features of renal amyloidosis: An analysis of 32 patients in a single Chinese centre[J]. NEPHROLOGY,2010,15(1):102-107.
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