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学科主题基础医学
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells
Xie, Ping1,2; Tang, Ying1; Shen, Shan1,3; Wang, Yunyan4; Xing, Guichun1; Yin, Yuxin5; He, Fuchu1,2; Zhang, Lingqiang1,3
关键词Protein ubiquitination Proteasomal degradation Ubiquitin ligase KLF2 Smurf1
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2011-04-01
DOI10.1016/j.bbrc.2011.03.016
407期:1页:254-259
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]TRANSCRIPTION FACTOR ; FAMILY ; DIFFERENTIATION ; APOPTOSIS ; PROTEINS ; MICE ; WW
英文摘要

Kruppel-like factor 2 (KLF2) has been demonstrated to be essential for normal lung development, erythroid differentiation, T-cell differentiation, migration and homing. However, the mechanisms underlying the regulation of KLF2, in particular its responsible E3 ligase is still unclear. Here we show that the homologous to E6AP carboxyl terminus (HECT)-type ubiquitin ligase Smad ubiquitination regulatory factor 1 (Smurf1) interacts with and targets KLF2 for poly-ubiquitination and proteasomal degradation specifically in lung cancer H1299 cells. The catalytic ligase activity of Smurf1 is required for it to regulate KLF2. Consequently, Smurf1 represses the transcriptional factor activity of KLF2 and regulates the expression its downstream genes such as CD62L and Wee1. This study provided the first evidence that Smurf1 functions as an E3 ligase to promote the ubiquitination and proteasomal degradation of KLF2. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000289541900047
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被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57852
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China
3.Anhui Med Univ, Sch Life Sci, Hefei 230032, Anhui, Peoples R China
4.Jining 2 Peoples Hosp, Dept Orthopaed, Jining 272049, Shandong, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
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Xie, Ping,Tang, Ying,Shen, Shan,et al. Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(1):254-259.
APA Xie, Ping.,Tang, Ying.,Shen, Shan.,Wang, Yunyan.,Xing, Guichun.,...&Zhang, Lingqiang.(2011).Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,407(1),254-259.
MLA Xie, Ping,et al."Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 407.1(2011):254-259.
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