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学科主题: 基础医学
题名:
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells
作者: Xie, Ping1,2; Tang, Ying1; Shen, Shan1,3; Wang, Yunyan4; Xing, Guichun1; Yin, Yuxin5; He, Fuchu1,2; Zhang, Lingqiang1,3
关键词: Protein ubiquitination ; Proteasomal degradation ; Ubiquitin ligase ; KLF2 ; Smurf1
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2011-04-01
DOI: 10.1016/j.bbrc.2011.03.016
卷: 407, 期:1, 页:254-259
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: TRANSCRIPTION FACTOR ; FAMILY ; DIFFERENTIATION ; APOPTOSIS ; PROTEINS ; MICE ; WW
英文摘要:

Kruppel-like factor 2 (KLF2) has been demonstrated to be essential for normal lung development, erythroid differentiation, T-cell differentiation, migration and homing. However, the mechanisms underlying the regulation of KLF2, in particular its responsible E3 ligase is still unclear. Here we show that the homologous to E6AP carboxyl terminus (HECT)-type ubiquitin ligase Smad ubiquitination regulatory factor 1 (Smurf1) interacts with and targets KLF2 for poly-ubiquitination and proteasomal degradation specifically in lung cancer H1299 cells. The catalytic ligase activity of Smurf1 is required for it to regulate KLF2. Consequently, Smurf1 represses the transcriptional factor activity of KLF2 and regulates the expression its downstream genes such as CD62L and Wee1. This study provided the first evidence that Smurf1 functions as an E3 ligase to promote the ubiquitination and proteasomal degradation of KLF2. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2011CB910602 ; 2007CB914601 ; 2010CB912202 ; 30830029 ; 30970601 ; 31070693 ; 2009ZX09503-002 ; 2009ZX09301-002
项目资助者: Chinese National Basic Research Programs ; Chinese National Natural Science Foundation ; National Key Technologies R& ; D Program for New Drugs
WOS记录号: WOS:000289541900047
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57852
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Beijing Inst Radiat Med, Beijing Proteome Res Ctr, State Key Lab Prote, Beijing 100850, Peoples R China
3.Anhui Med Univ, Sch Life Sci, Hefei 230032, Anhui, Peoples R China
4.Jining 2 Peoples Hosp, Dept Orthopaed, Jining 272049, Shandong, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Xie, Ping,Tang, Ying,Shen, Shan,et al. Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,407(1):254-259.
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