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学科主题: 基础医学
题名:
Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas
作者: Li, Haiyan1; Wang, Qun1; Gao, Fei1; Zhu, Faliang1; Wang, Xiaoyan1; Zhou, Chengjun2; Liu, Chunmei1; Chen, Yingyu3; Ma, Chunhong1; Sun, Wensheng1; Zhang, Lining1
关键词: programmed cell death 5 ; glioma ; gene expression
刊名: ONCOLOGY REPORTS
发表日期: 2008-09-01
DOI: 10.3892/or_00000044
卷: 20, 期:3, 页:573-579
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GENE-EXPRESSION ; TUMOR-CELLS ; APOPTOSIS ; LEUKEMIA ; CANCER ; LEVEL ; DEATH ; LIVER
英文摘要:

Programmed cell death 5 (PDCD5) is a novel apoptosis-promoting protein. Recently, a decreased expression of PDCD5 has been found in several types of human tumors. However, the expression level of PDCD5 in human gliomas has not been investigated. In the present study, we examined the expression of PDCD5 in 88 human glioma samples at both mRNA and protein levels by RT-PCR, Western blotting and immunohistochemistry. We found that 53.3% (16/30) of the glioma samples had a reduced expression of PDCD5 mRNA and 70.5% (62/88) had a reduced expression of the PDCD5 protein as compared to normal brain tissue. Furthermore, we studied the correlation of the expression level of PDCD5 with the clinicopathological grade and survival of patients with astrocytomas. Although longitudinal studies of a cohort of patients with astrocytoma revealed that PDCD5 expression was not able to predict clinical outcome (p > 0.05), a decreased expression of PDCD5 correlated significantly with high-grade astrocytomas (p < 0.001). In conclusion, our data suggest that reduced PDCD5 expression may contribute to the pathogenesis of human gliomas.

语种: 英语
WOS记录号: WOS:000259259200014
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57856
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Shandong Univ, Sch Med, Inst Immunol, Jinan 250012, Shandong, Peoples R China
2.Shandong Univ, Hosp 2, Dept Pathol, Jinan 250021, Shandong, Peoples R China
3.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Li, Haiyan,Wang, Qun,Gao, Fei,et al. Reduced expression of PDCD5 is associated with high-grade astrocytic gliomas[J]. ONCOLOGY REPORTS,2008,20(3):573-579.
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