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The profiling and identification of the metabolites of (+)-catechin and study on their distribution in rats by HPLC-DAD-ESI-IT-TOF-MSn technique
Liang, Jing1; Xu, Feng1; Zhang, Ya-Zhou1; Zang, Xin-Yu1; Wang, Dan1; Shang, Ming-Ying1; Wang, Xuan1; Chui, De-Hua2,3,4; Cai, Shao-Qing1
关键词(+)-catechin Metabolic Profile Distribution Lc-ms
刊名BIOMEDICAL CHROMATOGRAPHY
2014-03-01
DOI10.1002/bmc.3034
28期:3页:401-411
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]FLAVONOID METABOLISM ; SMALL-INTESTINE ; TEA CATECHINS ; GUINEA PIG ; (&amp ; )-CATECHIN ; EXCRETION ; URINE ; LIVER
英文摘要

(+)-Catechin, a potential beneficial compound to human health, is widely distributed in plants and foods. A high-performance liquid chromatography with diode array detector and combined with electrospray ionization ion trap time-of-flight multistage mass spectrometry method was applied to profile and identify the metabolites of (+)-catechin in rats and to study the distribution of these metabolites in rat organs for the first time. In total, 51 phase II metabolites (44 new) and three phase I metabolites were tentatively identified, comprising 16 (+)-catechin conjugates, 14 diarylpropan-2-ol metabolites, 6 phenyl valerolactone metabolites and 18 aromatic acid metabolites. Further, 19 phase II metabolites were new compounds. The in vivo metabolic reactions of (+)-catechin in rats were found to be ring-cleavage, sulfation, glucuronidation, methylation, dehydroxylation and dehydrogenation. The numbers of detected metabolites in urine, plasma, small intestine, kidney, liver, lung, heart, brain and spleen were 53, 23, 27, 9, 7, 5, 3, 2 and 1, respectively. This indicated that small intestine, kidney and liver were the major organs for the distribution of (+)-catechin metabolites. In addition, eight metabolites were found to possess bioactivities according to literature. These results are very helpful for better comprehension of the in vivo metabolism of (+)-catechin and its pharmacological actions, and also can give strong indications on the effective forms of (+)-catechin in vivo. Copyright (c) 2013 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000330839500014
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57864
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
3.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing, Peoples R China
4.Peking Univ, Minist Publ Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liang, Jing,Xu, Feng,Zhang, Ya-Zhou,et al. The profiling and identification of the metabolites of (+)-catechin and study on their distribution in rats by HPLC-DAD-ESI-IT-TOF-MSn technique[J]. BIOMEDICAL CHROMATOGRAPHY,2014,28(3):401-411.
APA Liang, Jing.,Xu, Feng.,Zhang, Ya-Zhou.,Zang, Xin-Yu.,Wang, Dan.,...&Cai, Shao-Qing.(2014).The profiling and identification of the metabolites of (+)-catechin and study on their distribution in rats by HPLC-DAD-ESI-IT-TOF-MSn technique.BIOMEDICAL CHROMATOGRAPHY,28(3),401-411.
MLA Liang, Jing,et al."The profiling and identification of the metabolites of (+)-catechin and study on their distribution in rats by HPLC-DAD-ESI-IT-TOF-MSn technique".BIOMEDICAL CHROMATOGRAPHY 28.3(2014):401-411.
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