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Effects of alpha-tocopherol on noise-induced hearing loss in guinea pigs
Hou, FX; Wang, S; Zhai, SQ; Hu, YY; Yang, WY; He, LH
关键词Noise Alpha-tocopherol Noise-induced Hearing Loss Antioxidant Guinea Pig
刊名HEARING RESEARCH
2003-05-01
DOI10.1016/S0378-5955(03)00065-0
179期:1-2页:1-8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Audiology & Speech-Language Pathology ; Neurosciences ; Otorhinolaryngology
研究领域[WOS]Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
关键词[WOS]CAROTENE CANCER PREVENTION ; TEMPORARY THRESHOLD SHIFTS ; INDUSTRIAL NOISE ; VITAMIN-E ; INNER-EAR ; NEUROTROPHIC FACTOR ; ACOUSTIC TRAUMA ; COCHLEAR DAMAGE ; FREE-RADICALS ; EXPOSURE
英文摘要

Preventing noise-induced hearing loss (NIHL) by antioxidants is based on the hypothesis that generation of reactive oxygen species is one of the causes of NIHL. alpha-Tocopherol is a naturally occurring antioxidant with no noticeable side effects. In this study, we attempted to protect guinea pigs from developing NIHL by administering alpha-tocopherol. Pigmented male guinea pigs were exposed to a noise (4 kHz octave band, 100 dB SPL), 8 h/day for 3 days consecutively. alpha-Tocopherol (10 mg/kg or 50 mg/kg daily) was given by intraperitoneal injection from 3 days before through 3 days after the noise exposure. Auditory evoked brainstem, response (ABR) thresholds at 2, 4 and 8 kHz were recorded prior to the experiment, immediately post-noise, 2 and 8 days post-noise. On day 8 post-noise, after the ABR recording, guinea pigs were decapitated and the cochleae were removed for cochlear surface preparations and scanning electron microscope (SEM) study. ABR threshold shifts of groups receiving alpha-tocopherol were significantly smaller than those of groups not receiving alpha-tocopherol at all frequencies and all time points tested except that of group 3 at 8 kHz 8 days post-noise. No hair cell loss was seen on the surface preparations, but stereocilia loss was found by SEM study. The noise-induced stereocilia loss was significantly decreased by alpha-tocopherol: These results indicate that alpha-tocopherol can attenuate the noise-induced cochlear damage. Further investigations on the preventive effect of alpha-tocopherol on NIHL in noise-exposed workers are necessary. (C) 2003 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000182950900001
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57865
专题北京大学公共卫生学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat Hlth, Beijing 100871, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Inst Otolaryngol, Beijing, Peoples R China
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GB/T 7714
Hou, FX,Wang, S,Zhai, SQ,et al. Effects of alpha-tocopherol on noise-induced hearing loss in guinea pigs[J]. HEARING RESEARCH,2003,179(1-2):1-8.
APA Hou, FX,Wang, S,Zhai, SQ,Hu, YY,Yang, WY,&He, LH.(2003).Effects of alpha-tocopherol on noise-induced hearing loss in guinea pigs.HEARING RESEARCH,179(1-2),1-8.
MLA Hou, FX,et al."Effects of alpha-tocopherol on noise-induced hearing loss in guinea pigs".HEARING RESEARCH 179.1-2(2003):1-8.
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